Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis
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DOI: 10.1038/s41598-017-04538-3
Abstract: Map3k8 has been proposed as a useful target for the treatment of inflammatory diseases. We show here that during lipopolysaccharide-induced emergency granulopoiesis, Map3k8 deficiency strongly impairs the increase in circulating mature (Ly6GhighCD11b+) and immature (Ly6GlowCD11b+)… read more here.
Keywords: map3k8; emergency granulopoiesis; lipopolysaccharide induced; induced emergency ... See more keywords
Shigella-Induced Emergency Granulopoiesis Protects Zebrafish Larvae from Secondary Infection
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DOI: 10.1128/mbio.00933-18
Abstract: ABSTRACT Emergency granulopoiesis is a hematopoietic program of stem cell-driven neutrophil production used to counteract immune cell exhaustion following infection. Shigella flexneri is a Gram-negative enteroinvasive pathogen controlled by neutrophils. In this study, we use… read more here.
Keywords: infection; shigella; emergency granulopoiesis; stem ... See more keywords
Regulation of emergency granulopoiesis during infection
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DOI: 10.3389/fimmu.2022.961601
Abstract: During acute infectious and inflammatory conditions, a large number of neutrophils are in high demand as they are consumed in peripheral organs. The hematopoietic system rapidly responds to the demand by turning from steady state… read more here.
Keywords: granulopoiesis; regulation emergency; emergency granulopoiesis; granulopoiesis infection ... See more keywords
Activation of formyl peptide receptor 2 by WKYMVm enhances emergency granulopoiesis through phospholipase C activity
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DOI: 10.5483/bmbrep.2018.51.8.080
Abstract: Emergency granulopoiesis is a very important strategy to supply efficient neutrophil number in response to infection. However, molecular mechanism involved in this process remains unclear. Here, we found that administration of WKYMVm, an immune modulating… read more here.
Keywords: emergency; wkymvm; emergency granulopoiesis; peptide receptor ... See more keywords