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Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21888
Abstract: Purinergic signaling is mediated through extracellular nucleotides (adenosine 5′‐triphosphate, uridine‐5'‐triphosphate, adenosine diphosphate, uridine‐5'‐diphosphate, and adenosine) that serve as signaling molecules. In the early 1990s, purines and pyrimidine receptors were cloned and characterized drawing the attention…
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Keywords:
pharmacological tool;
purinergic receptors;
emerging pharmacological;
modulators emerging ... See more keywords
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Published in 2020 at "Intensive Care Medicine"
DOI: 10.1007/s00134-020-06141-z
Abstract: ARDS, first described in 1967, is the commonest form of acute severe hypoxemic respiratory failure. Despite considerable advances in our knowledge regarding the pathophysiology of ARDS, insights into the biologic mechanisms of lung injury and…
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Keywords:
medicine;
pharmacological therapies;
ards covid;
therapies ards ... See more keywords
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Published in 2017 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2017.06.129
Abstract: Neurodegenerative disorders are emerging as leading contributors to the global disease burden. While some drug-based approaches have been designed to limit or prevent neuronal loss following acute damage or chronic neurodegeneration, regeneration of functional neurons…
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Keywords:
neurogenesis endogenous;
pharmacological approaches;
approaches promote;
glial cells ... See more keywords
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Published in 2019 at "CNS Spectrums"
DOI: 10.1017/s109285291900124x
Abstract: Schizophrenia remains one of the most severe medical diseases. Current dopamine modulating first-generation and second-generation antipsychotics target mainly positive symptoms, but not/inadequately negative and cognitive symptoms. Additional challenges include non-adherence and adverse effects, especially cardiometabolic…
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Keywords:
positive symptoms;
review;
keeping therapeutic;
emerging pharmacological ... See more keywords
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Published in 2021 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2021.1892641
Abstract: ABSTRACT Abstract introduction: The number of medications approved for AUD is small and they generally have limited efficacy. We need new pharmacotherapies for the management of AUD. Areas covered: In this review, the authors aim…
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Keywords:
pharmacological approaches;
approaches alcohol;
approved emerging;
new approved ... See more keywords
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Published in 2022 at "Life"
DOI: 10.3390/life12040536
Abstract: Headaches in children and adolescents have high incidence and prevalence rates, with consequent elevated disability costs to individuals and the community. Pediatric migraine is a disorder with substantial clinical differences compared to the adult form.…
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Keywords:
treatments migraine;
emerging pharmacological;
pharmacological treatments;
migraine pediatric ... See more keywords