Emerging physiological and pathological roles of MeCP2 in non-neurological systems.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108768
Abstract: Numerous neurological and non-neurological disorders are associated with dysfunction of epigenetic modulators, and methyl CpG binding protein 2 (MeCP2) is one of such proteins. Initially identified as a transcriptional repressor, MeCP2 specifically binds to methylated… read more here.
Keywords: emerging physiological; non neurological; physiological pathological; pathological roles ... See more keywords
USP30: Structure, Emerging Physiological Role, and Target Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.851654
Abstract: Ubiquitin-specific protease 30 (USP30) is a deubiquitinating enzyme (DUB) belonging to the USP subfamily, which was found localized in the mitochondrial outer membrane and peroxisomes owing to its unique transmembrane domain. Structural study revealed that… read more here.
Keywords: emerging physiological; structure; role; physiological role ... See more keywords