Decoding pseudouridine: an emerging target for therapeutic development.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2022.03.008
Abstract: Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification and is widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring distinct structural and functional properties to the RNA molecules that it… read more here.
Keywords: pseudouridine; emerging target; therapeutic development; decoding pseudouridine ... See more keywords
Emerging Target-Directed Approaches for the Treatment and Diagnosis of Microbial Infections.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01212
Abstract: With the rising levels of drug resistance, developing efficient antimicrobial therapies has become a priority. A promising strategy is the conjugation of antibiotics with relevant moieties that can potentiate their activity by target-directing. The conjugation… read more here.
Keywords: emerging target; approaches treatment; directed approaches; target directed ... See more keywords
Autophagy: An Emerging Target for Developing Effective Analgesics
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c06949
Abstract: Inadequate treatment of acute and chronic pain causes depression, anxiety, sleep disturbances, and increased mortality. Abuse and overdose of opioids and the side effects associated with chronic use of NSAID illustrate the need for development… read more here.
Keywords: emerging target; autophagy emerging; effective analgesics; developing effective ... See more keywords
Ribosomal biogenesis as an emerging target of neurodevelopmental pathologies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14576
Abstract: Development of the nervous system is carried out by complex gene expression programs that are regulated at both transcriptional and translational level. In addition, quality control mechanisms such as the TP53‐mediated apoptosis or neuronal activity‐stimulated… read more here.
Keywords: ribosomal biogenesis; biogenesis emerging; neurodevelopmental pathologies; emerging target ... See more keywords
Carotid body: an emerging target for cardiometabolic co‐morbidities
Sign Up to like & getrecommendations! Published in 2023 at "Experimental Physiology"
DOI: 10.1113/ep090090
Abstract: What is the topic of this review? Regarding the global metabolic syndrome crisis, this review focuses on common mechanisms for high blood sugar and high blood pressure. Connections are made between the homeostatic regulation of… read more here.
Keywords: emerging target; target cardiometabolic; carotid body; blood ... See more keywords
Elabela peptide: an emerging target in therapeutics.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug targets"
DOI: 10.2174/1389450123666220826160123
Abstract: Elabela, a bioactive micropeptide, is recognized as the second endogenous ligand for Apelin receptor and is widely distributed in different tissues and organs. Elabela plays important role in various physiological processes such blood pressure control,… read more here.
Keywords: emerging target; target therapeutics; peptide emerging; elabela peptide ... See more keywords
Emerging target discovery and drug repurposing opportunities in chordoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1009193
Abstract: The development of effective and personalized treatment options for patients with rare cancers like chordoma is hampered by numerous challenges. Biomarker-guided repurposing of therapies approved in other indications remains the fastest path to redefining the… read more here.
Keywords: oncology; emerging target; chordoma; discovery drug ... See more keywords
Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11111720
Abstract: Galectin-7 is a soluble unglycosylated lectin that is able to bind specifically to β-galactosides. It has been described to be involved in apoptosis, proliferation and differentiation, but also in cell adhesion and migration. Several disorders… read more here.
Keywords: galectin; target cellular; functions inhibition; emerging target ... See more keywords
Ligand design for riboswitches, an emerging target class for novel antibiotics.
Sign Up to like & getrecommendations! Published in 2017 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2017-0063
Abstract: Riboswitches are cis-acting gene regulatory elements and constitute potential targets for new antibiotics. Recent studies in this field have started to explore these targets for drug discovery. New ligands found by fragment screening, design of… read more here.
Keywords: ligand design; design riboswitches; design; emerging target ... See more keywords