Emerging targets of inflammation and tear secretion in dry eye disease.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.02.006
Abstract: The underlying mechanisms of dry eye are thought to be part of a vicious circle involving a hyperosmolarity-triggered inflammatory cascade, resulting in loss of goblet cells and glycocalyx mucin and observed corneal and conjunctival epithelial… read more here.
Keywords: tear secretion; vicious circle; eye; dry eye ... See more keywords
Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112311
Abstract: Nonalcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease in the world, which is characterized by liver fat accumulation unrelated to excessive drinking. Indeed, it attracts growing attention and becomes a global… read more here.
Keywords: fatty liver; disease; targets potential; potential therapeutic ... See more keywords
Novel and emerging targets for cholangiocarcinoma progression: therapeutic implications
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2029412
Abstract: ABSTRACT Introduction Cholangiocarcinoma (CCA) is a heterogeneous group of aggressive biliary malignancies. While surgery and liver transplantation are the only potentially curative modalities for early-stage disease, limited options are available for most patients with incurable-stage… read more here.
Keywords: novel emerging; targets cholangiocarcinoma; cholangiocarcinoma progression; progression therapeutic ... See more keywords
Emerging targets and uses of neuromodulation for pain
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2019.1567332
Abstract: ABSTRACT Introduction: There has been great development in the testing of invasive and non-invasive neuromodulation for chronic pain. To date, it is known that central and peripheral stimulation targets, combined or not, may influence chronic… read more here.
Keywords: stimulation; targets uses; neuromodulation; emerging targets ... See more keywords
New emerging targets in cancer immunotherapy: the role of TIM3
Sign Up to like & getrecommendations! Published in 2019 at "ESMO Open"
DOI: 10.1136/esmoopen-2019-000497
Abstract: Currently, the programmed death-1/programmed death ligand-1 and the cytotoxic T-lymphocyte-associated protein 4 are the two commonly targeted immune-checkpoint inhibition pathways. These drugs have significantly improved the prognosis of many cancer types. While immune-checkpoint inhibitors have… read more here.
Keywords: immune checkpoint; targets cancer; checkpoint; cancer ... See more keywords
New emerging targets in cancer immunotherapy beyond CTLA-4, PD-1 and PD-L1: Introducing an “ESMO Open – Cancer Horizons” Series
Sign Up to like & getrecommendations! Published in 2019 at "ESMO Open"
DOI: 10.1136/esmoopen-2019-000501
Abstract: The ability of tumour cells to escape the surveillance and elimination by the immune system represents one of the hallmarks of cancer.1 2 This concept of immune control against cancer development, recognised more than 60… read more here.
Keywords: esmo open; targets cancer; cancer immunotherapy; cancer ... See more keywords
Melanocortin receptors: emerging targets for the treatment of pigmentation, inflammation, stress, weight disorders and sexual dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug targets"
DOI: 10.2174/1389450124666221108143006
Abstract: Melanocortins are tiny protein molecules formed by the post-translational cleavage of proopiomelanocortin. These are bioactive peptides that are responsible for human and lower animal pigmentation patterns, energy homeostasis, and sexual function modulation. These peptides regulate… read more here.
Keywords: melanocortin receptors; targets treatment; receptors emerging; pigmentation ... See more keywords
EDITORIAL; GPCR Drug Discovery: Emerging Targets, Novel Approaches and Future Trends.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/156802661916190828093500
Abstract: read more here.
Keywords: targets novel; gpcr drug; editorial gpcr; drug discovery ... See more keywords
Phosphoenolpyruvate carboxykinases as emerging targets in cancer therapy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1196226
Abstract: Metabolic reprogramming is commonly accompanied by alterations in the expression of metabolic enzymes. These metabolic enzymes not only catalyze the intracellular metabolic reaction, but also participate in a series of molecular events to regulate tumor… read more here.
Keywords: carboxykinases emerging; targets cancer; phosphoenolpyruvate; cancer therapy ... See more keywords