Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases
Sign Up to like & getrecommendations! Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900177
Abstract: No drug has been approved to prevent neuronal cell loss in patients suffering from Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of the underlying molecular causes, therapies target cognitive functional improvement and… read more here.
Keywords: acting mao; emerging therapeutic; dual acting; drug ... See more keywords
CD36: an emerging therapeutic target for cancer and its molecular mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-022-03957-8
Abstract: Tumor cells need to rewire their metabolic pathways to regulate the nutrient uptake and metabolism to sustain the energy production. Lipids are important components of energy sources for tumor metabolism. Tumor cells rely on various… read more here.
Keywords: cancer; tumor; emerging therapeutic; cd36 emerging ... See more keywords
Engineered protein nanodrug as an emerging therapeutic tool
Sign Up to like & getrecommendations! Published in 2022 at "Nano Research"
DOI: 10.1007/s12274-022-4103-2
Abstract: Functional proteins are the most versatile macromolecules. They can be obtained by extraction from natural sources or by genetic engineering technologies. The outstanding selectivity, specificity, binding activity, and biocompatibility endow engineered proteins with outstanding performance… read more here.
Keywords: emerging therapeutic; therapeutic tool; therapeutic proteins; engineered protein ... See more keywords
Focused Ultrasound: An Emerging Therapeutic Modality for Neurologic Disease
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DOI: 10.1007/s13311-017-0515-1
Abstract: Therapeutic ultrasound is only beginning to be applied to neurologic conditions, but the potential of this modality for a wide spectrum of brain applications is high. Engineering advances now allow sound waves to be targeted… read more here.
Keywords: focused ultrasound; emerging therapeutic; disease; therapeutic modality ... See more keywords
Emerging therapeutic agents in osteoarthritis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.02.034
Abstract: Osteoarthritis (OA) is the most common joint disorder and a leading cause of disability. Current treatments for OA can improve symptoms but do not delay the progression of disease. In the last years, much effort… read more here.
Keywords: pharmacology; therapeutic agents; emerging therapeutic; agents osteoarthritis ... See more keywords
Emerging Therapeutic Strategies for Fragile X Syndrome: Q&A
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00674
Abstract: Understanding how best to treat aspects of Fragile X syndrome has the potential to improve the quality of life of affected individuals. Such an effective therapy has, as yet, remained elusive. In this article, we… read more here.
Keywords: strategies fragile; emerging therapeutic; therapeutic strategies; fragile syndrome ... See more keywords
Emerging therapeutic targets for NASH: key innovations at the preclinical level
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2020.1728742
Abstract: ABSTRACT Introduction: nonalcoholic steatohepatitis (NASH) is a globally emerging health problem, mainly caused by increasing trends in the prevalence of obesity and metabolic syndrome. Patients with NASH are mainly affected by cardiovascular risk and extrahepatic… read more here.
Keywords: emerging therapeutic; key innovations; therapeutic targets; innovations preclinical ... See more keywords
Polyglutamine spinocerebellar ataxias: emerging therapeutic targets
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2020.1827394
Abstract: ABSTRACT Introduction Six of the most frequent dominantly inherited spinocerebellar ataxias (SCAs) worldwide – SCA1, SCA2, SCA3, SCA6, SCA7, and SCA17 – are caused by an expansion of a polyglutamine (polyQ) tract in the corresponding… read more here.
Keywords: targets polyglutamine; emerging therapeutic; polyglutamine spinocerebellar; therapeutic targets ... See more keywords
Emerging therapeutic targets for cardiac hypertrophy
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2031974
Abstract: ABSTRACT Introduction Cardiac hypertrophy is associated with adverse outcomes across cardiovascular disease states. Despite strides over the last three decades in identifying molecular and cellular mechanisms driving hypertrophy, the link between pathophysiological stress stimuli and… read more here.
Keywords: emerging therapeutic; therapeutic targets; hypertrophy; heart ... See more keywords
Neuropathogenesis of HIV and emerging therapeutic targets
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2100253
Abstract: ABSTRACT Introduction HIV infection causes a wide range of neurological complications, many of which are among the most common complications of chronic HIV infection in the era of combined antiretroviral therapy. These neurological conditions arise… read more here.
Keywords: emerging therapeutic; neuropathogenesis hiv; hiv associated; targets neuropathogenesis ... See more keywords
Emerging therapeutic targets for retinoblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2158812
Abstract: ABSTRACT Introduction Retinoblastoma (Rb) is an early childhood intraocular tumor of the retina and is managed by multimodal therapeutic approaches. Recent advanced targeted delivery of chemotherapeutic drugs to the eye has improved the possibility of… read more here.
Keywords: emerging therapeutic; targets retinoblastoma; treatment; biology ... See more keywords