Emerin induces nuclear breakage in Xenopus extract and early embryos
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DOI: 10.1091/mbc.e18-05-0277
Abstract: Emerin is an inner nuclear membrane protein often mutated in Emery–Dreifuss muscular dystrophy. Because emerin has diverse roles in nuclear mechanics, cytoskeletal organization, and gene expression, it has been difficult to elucidate its contribution to… read more here.
Keywords: emerin; emerin induces; egg extract; nuclear breakage ... See more keywords
Emerin prevents BAF-mediated aggregation of lamin A on chromosomes in telophase to allow nuclear membrane expansion and nuclear lamina formation
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DOI: 10.1091/mbc.e22-01-0007
Abstract: Several studies have suggested a role for the LEM-domain protein emerin and the DNA binding factor BAF in nuclear envelope reformation after mitosis, but the exact molecular mechanisms are not understood. Using HeLa cells deficient… read more here.
Keywords: lamin; aggregation; emerin; nuclear membrane ... See more keywords
Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery
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DOI: 10.3389/fcell.2022.1007120
Abstract: X-Linked Emery-Dreifuss muscular dystrophy is caused by mutations in the gene encoding emerin. Emerin is an inner nuclear membrane protein important for repressive chromatin organization at the nuclear periphery. Myogenic differentiation is a tightly regulated… read more here.
Keywords: nuclear periphery; repressive chromatin; emerin; ezh2 g9a ... See more keywords
The Role of Emerin in Cancer Progression and Metastasis
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DOI: 10.3390/ijms222011289
Abstract: It is commonly recognized in the field that cancer cells exhibit changes in the size and shape of their nuclei. These features often serve as important biomarkers in the diagnosis and prognosis of cancer patients.… read more here.
Keywords: progression metastasis; emerin; size; role ... See more keywords