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   Articles with "emetine" as a keyword



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The Trans Golgi Region is a Labile Intracellular Ca2+ Store Sensitive to Emetine

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-35280-z

Abstract: The Golgi apparatus (GA) is a bona fide Ca2+ store; however, there is a lack of GA-specific Ca2+ mobilizing agents. Here, we report that emetine specifically releases Ca2+ from GA in HeLa and HL-1 atrial… read more here.

Keywords: emetine; trans golgi; ca2 store; golgi region ... See more keywords
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Application of emetine in SARS-CoV-2 treatment: regulation of p38 MAPK signaling pathway for preventing emetine-induced cardiac complications

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recommendations! Published in 2022 at "Cell Cycle"

DOI: 10.1080/15384101.2022.2100575

Abstract: ABSTRACT Emetine is one of the most highly potent anti-SARS-CoV-2 agents ever identified. In addition to having strong anti-SARS-CoV-2 activities, emetine has other valuable therapeutic effects such as strong anti-inflammatory and anti-arterial pulmonary hypertension (APH)… read more here.

Keywords: emetine; cardiac complications; mapk signaling; p38 mapk ... See more keywords

Lead Optimization of Dehydroemetine for Repositioned Use in Malaria

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recommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.01444-19

Abstract: Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel antimalarial treatments. The antiamoebic compound emetine dihydrochloride has been identified as a potent in vitro inhibitor of… read more here.

Keywords: multidrug resistant; drug; emetine dihydrochloride; dehydroemetine ... See more keywords

Emetine and Indirubin- 3- monoxime interaction with human brain acetylcholinesterase: A computational and statistical analysis.

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recommendations! Published in 2022 at "Cellular and molecular biology"

DOI: 10.14715/cmb/2021.67.4.12

Abstract: Alzheimer's disease is a chronic neurodegenerative ailment and the most familiar type of dementia in the older population with no effective cure to date. It is characterized by a decrease in memory, associated with the… read more here.

Keywords: interaction; brain acetylcholinesterase; emetine; energy ... See more keywords
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Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.14393

Abstract: Despite improved clinical outcomes of diffuse large B-cell lymphoma, a certain proportion of patients still develop a primary refractory disease. To overcome these lymphomas that are intractable to existing treatment strategies, the tumor microenvironment has… read more here.

Keywords: lymphoma; myc rearrangement; emetine; lymphoma cells ... See more keywords

Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments

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recommendations! Published in 2022 at "Life Science Alliance"

DOI: 10.26508/lsa.202201560

Abstract: This study clarifies the long-standing misuse of emetine as a lagging strand synthesis-specific inhibitor. Emetine blocks the synthesis of both DNA strands by the inhibition of protein biosynthesis. DNA synthesis of the leading and lagging… read more here.

Keywords: emetine; inhibition; replication; proteosynthesis ... See more keywords