Emodin modulates gut microbial community and triggers intestinal immunity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Science of Food and Agriculture"
DOI: 10.1002/jsfa.12221
Abstract: Abstract BACKGROUND The gut microbiota (GM) plays an important role in human health and is being investigated as a possible target for new therapies. Although there are many studies showing that emodin can improve host… read more here.
Keywords: modulates gut; emodin; emodin modulates; microbial community ... See more keywords
Proteomic and metabolomic approaches elucidate the molecular mechanism of emodin against neuropathic pain through modulating the gamma‐aminobutyric acid (GABA)‐ergic pathway and PI3K/AKT/NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2023 at "Phytotherapy Research"
DOI: 10.1002/ptr.7704
Abstract: Neuropathic pain (NeP) is a major health concern. Due to the complex pathological mechanisms, management of NeP is challenging. Emodin, a natural anthraquinone derivative, exerts excellent analgesic effects. However, its mechanisms of action are still… read more here.
Keywords: pi3k akt; signaling pathway; neuropathic pain; emodin ... See more keywords
Emodin attenuates acute lung injury in Cecal-ligation and puncture rats.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106626
Abstract: Acute lung injury (ALI) is a major cause of sepsis-induced acute respiratory failure. Emodin has been considered to play a protective role for acute lung edema in cecal ligation and puncture (CLP)-induced sepsis model. In… read more here.
Keywords: sepsis; cecal ligation; ligation puncture; emodin ... See more keywords
Emodin protects hyperglycemia-induced injury in PC-12 cells by up-regulation of miR-9
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2018.03.009
Abstract: BACKGROUND Diabetic foot is a severe complication of diabetes mellitus, mainly caused by diabetic peripheral neuropathy. The objective of this study was to investigate the function of emodin (a neuroprotective agent reported previously) in diabetic… read more here.
Keywords: emodin; induced injury; high glucose; regulation mir ... See more keywords
Emodin attenuates titanium particle‐induced osteolysis and RANKL‐mediated osteoclastogenesis through the suppression of IKK phosphorylation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.02.008
Abstract: &NA; Aseptic loosening due to wear particles is a serious challenge for orthopedic surgeons, sabotaging the long‐term success of total joint arthroplasty. The existing treatments for aseptic loosening are still far from satisfactory, necessitating more… read more here.
Keywords: titanium particle; emodin; particle induced; induced osteolysis ... See more keywords
Enhanced absorption and inhibited metabolism of emodin by 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside: Possible mechanisms for Polygoni Multiflori Radix-induced liver injury.
Sign Up to like & getrecommendations! Published in 2017 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(17)30067-5
Abstract: Polygoni Multiflori Radix (PMR) has been commonly used as a tonic in China for centuries. However, PMR-associated hepatotoxicity is becoming a safety issue. In our previous in vivo study, an interaction between stilbenes and anthraquinones… read more here.
Keywords: absorption; emodin; metabolism emodin; polygoni multiflori ... See more keywords
Network Pharmacology Experiments Show That Emodin Can Exert a Protective Effect on MCAO Rats by Regulating Hif-1α/VEGF-A Signaling
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01897
Abstract: Modern pharmacological studies have shown that emodin, the main effective component of rhubarb, has good anti-inflammatory and antioxidant effects, but its pharmacodynamic mechanism remains unclear yet. This study aims to elucidate the multitarget action mechanism… read more here.
Keywords: pharmacology; emodin; hif vegf; network pharmacology ... See more keywords
Magnetic liposomal emodin composite with enhanced killing efficiency against breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c8bm01530a
Abstract: As an active natural ingredient extracted from the plant Rheum palmatum, emodin exhibits various pharmacological activities, especially the inhibition of tumor growth and migration. However, the anticancer activity of emodin is limited mainly due to… read more here.
Keywords: liposomal emodin; emodin; magnetic liposomal; killing efficiency ... See more keywords
Emodin ameliorates renal injury in BXSB mice by modulating TNF-α/ICAM-1
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20202551
Abstract: Abstract The purpose of the present study was to explore the effects of emodin on renal injury in a BXSB mouse model of lupus and its mechanisms. BXSB mice were fed different concentrations of emodin… read more here.
Keywords: dsdna antibody; anti dsdna; emodin; tnf icam ... See more keywords
Gamma irradiation of aloe-emodin induced structural modification and apoptosis through a ROS- and caspase-dependent mitochondrial pathway in stomach tumor cells
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2018.1440330
Abstract: Abstract Purpose: The changes in molecular structure and the physiological properties of a gamma-irradiated aloe-emodin were examined. Materials and methods: Aloe-emodin was gamma-irradiated at doses ranging from 0 to 150 kGy, and the molecular structure… read more here.
Keywords: aloe emodin; gamma irradiation; emodin; gamma irradiated ... See more keywords
Emodin Exerts its Therapeutic Effects Through Metabolic Remodeling in Severe Acute Pancreatitis-Related Intestinal Injury
Sign Up to like & getrecommendations! Published in 2023 at "Natural Product Communications"
DOI: 10.1177/1934578x231163995
Abstract: Background Intestinal injury caused by severe acute pancreatitis (SAP) can induce peripancreatic and systemic infection, and aggravate systemic inflammation. Emodin has demonstrated efficacy in mitigating SAP-associated intestinal injury. Although metabolites in tissues cause histopathophysiological changes,… read more here.
Keywords: metabolism; severe acute; emodin; metabolic remodeling ... See more keywords