Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
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DOI: 10.1124/dmd.121.000784
Abstract: The utilization of in vitro data to predict drug pharmacokinetics (PK) in vivo has been a consistent practice in early drug discovery for decades. However, its success is hampered by mispredictions attributed to uncharacterized biological… read more here.
Keywords: clearance; drug discovery; empirical scalars; prediction human ... See more keywords