Strategies Employed for the Development of PARP Inhibitors.
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DOI: 10.1007/978-1-4939-6993-7_18
Abstract: This chapter describes the approaches taken in the development of the first PARP inhibitor to enter clinical trial, rucaparib (now called Rubraca), in 2003. We describe the general principles of crystal-based drug design, the purification… read more here.
Keywords: parp inhibitors; employed development; parp; development parp ... See more keywords