THU0117 PHARMACOKINETICS AND SHORT-TERM SAFETY OF FILGOTINIB, A SELECTIVE JANUS KINASE 1 INHIBITOR, IN SUBJECTS WITH MODERATE HEPATIC IMPAIRMENT
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DOI: 10.1136/annrheumdis-2019-eular.2325
Abstract: Background Filgotinib (FIL) is an oral selective Janus kinase 1 (JAK1) inhibitor being developed to treat inflammatory diseases. Objectives This phase 1 study evaluated the pharmacokinetics (PK) and short-term safety of FIL in subjects with… read more here.
Keywords: gilead sciences; sciences inc; employee gilead; subjects moderate ... See more keywords
SAT0155 WHOLE BLOOD TRANSCRIPTIONAL CHANGES FOLLOWING SELECTIVE INHIBITION OF JANUS KINASE 1 (JAK1) BY FILGOTINIB IN MTX-NAÏVE ADULTS WITH MODERATELY-TO-SEVERELY ACTIVE RHEUMATOID ARTHRITIS (RA) (FINCH3)
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DOI: 10.1136/annrheumdis-2020-eular.3949
Abstract: Background: Filgotinib (FIL), an oral selective JAK1 inhibitor, has shown efficacy and safety in multiple phase 3 studies in adults with moderately-to-severely active rheumatoid arthritis (RA). We have previously described the molecular response to FIL… read more here.
Keywords: employee gilead; mtx; gilead sciences; sciences inc ... See more keywords