Safety and Efficacy of Anidulafungin in the Treatment of Invasive Candidiasis in Children
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DOI: 10.1093/ofid/ofx163.019
Abstract: Abstract Background Treatment with an echinocandin is recommended as first-line therapy of patients with invasive candidiasis including candidemia (ICC). Little is known about the efficacy and safety of anidulafungin (ANID) for the management of ICC… read more here.
Keywords: pfizer; treatment; safety; efficacy ... See more keywords
Phase 1 Clinical Trial of a Replication-Defective Human Cytomegalovirus (CMV) Vaccine
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DOI: 10.1093/ofid/ofx163.718
Abstract: Abstract Background Congenital CMV remains an unmet medical need worldwide. Naturally acquired CMV immunity in women prior to pregnancy has been shown effective in reducing maternal-fetal transmission. V160 is engineered as a replication-defective CMV, and… read more here.
Keywords: cmv; employee; merck employee; employee salary ... See more keywords
1644. A Potent Broadly Neutralizing Antibody Isolated From Human Memory B-cells Binding to Conserved Site IV on the RSV F Protein
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DOI: 10.1093/ofid/ofy209.114
Abstract: Abstract Background Respiratory syncytial virus (RSV) infection is a major public health burden for infants and the elderly worldwide. Currently, there are no approved vaccines and only one moderately effective marketed antibody (Synagis®) for the… read more here.
Keywords: rsv; site; merck employee; employee salary ... See more keywords
1350. Therapeutic Effects of Baloxavir Marboxil against Influenza A Virus Infection in Ferrets
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DOI: 10.1093/ofid/ofy210.1181
Abstract: Abstract Background Baloxavir marboxil (BXM) is a novel small molecule inhibitor of cap-dependent endonuclease that is essential for influenza virus transcription and replication. In this study, pharmacokinetic profiles of BXM and baloxavir acid (BXA), an… read more here.
Keywords: shionogi ltd; ltd employee; employee salary;
1991. A Prospective Pilot Evaluation of a Research Use Only (RUO) Prototype of a Highly Multiplexed Sample-to-Answer PCR System for the Detection of Pathogens From Positive Blood Culture
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DOI: 10.1093/ofid/ofy210.1647
Abstract: Abstract Background Rapid identification of causative agents from positive blood culture (PBC) can aid earlier targeted therapy, as well as reduce mortality, length of stay, and costs associated with systemic infections. The BioFire® Blood Culture… read more here.
Keywords: biofire; pbc; diagnostics llc; employee salary ... See more keywords
1996. Addressing Pulmonary Nocardiosis Risk in Immunocompromised Patients: Development and Validation of a Commercially Available PCR
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DOI: 10.1093/ofid/ofy210.1652
Abstract: Abstract Background Pulmonary nocardiosis is an infection targeting immunocompromised patients characterized by high mortality and requires nonfrontline antibiotics for treatment. Nocardiosis is currently confirmed or excluded by BAL fluid culture followed by further phenotypic identification… read more here.
Keywords: employee; viracor eurofins; clinical diagnostics; diagnostics employee ... See more keywords
2020. Concordance of Direct vs. Indirect Pathogen Detection Using the BioFire® System
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DOI: 10.1093/ofid/ofy210.1676
Abstract: Abstract Background Polymerase chain reaction (PCR) is a highly sensitive and specific method for pathogen detection. While direct methods enable rapid identification, they are limited by pathogen titer, available assays, or sample matrix. Transcriptomic analysis… read more here.
Keywords: biofire; llc employee; diagnostics llc; employee salary ... See more keywords