Multicomponent Enantioselective Synthesis of Tetrahydropyridazinones Employing Chiral α,β-Unsaturated Acylammonium Salts.
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DOI: 10.1021/acs.orglett.1c02044
Abstract: An enantioselective three-component reaction was developed for the synthesis of tetrahydropyridazinones employing chiral α,β-unsaturated acylammonium salts, malonates, and azodicarboxylates. An initial α-amination of a malonate with an azodicarboxylate and a subsequent chiral Lewis-base-catalyzed Michael/proton transfer/lactamization… read more here.
Keywords: tetrahydropyridazinones employing; chiral unsaturated; synthesis tetrahydropyridazinones; employing chiral ... See more keywords