EMT in Metastasis: Finding the Right Balance.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.05.033
Abstract: The epithelial-to-mesenchymal transition (EMT) is a key driver of cancer metastasis. In this issue of Developmental Cell, Aiello et al. (2018) demonstrate that an EMT mechanism involving protein internalization impacts cell migration, while Reichert et al. (2018)… read more here.
Keywords: right balance; metastasis; metastasis finding; emt metastasis ... See more keywords
Sirtinol, a SIRT1 inhibitor, inhibits the EMT and metastasis of 4T1 breast cancer cells and impacts the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2024 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2024.2412110
Abstract: Abstract Introduction The impact of epigenetic drugs on metastasis and the immunological microenvironment is poorly understood. In this study, we looked at how sirtinol, a SIRT1 inhibitor, affected epithelial-mesenchymal transition (EMT), metastasis, and the immune… read more here.
Keywords: cancer; emt metastasis; sirtinol sirt1; metastasis ... See more keywords
Abstract 1286: UNC5B promotes EMT and metastasis of pancreatic adenocarcinomas and expresses different isoforms that impact sensitivity to Netrin-1 blockade
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1286
Abstract: The axonal guidance receptor UNC5B is considered to be a tumor suppressor because it promotes apoptosis in the absence of its protein ligand, NTN1. But we find that UNC5B is not a tumor suppressor of… read more here.
Keywords: metastasis; promotes emt; pancreatic adenocarcinomas; unc5b promotes ... See more keywords