FAT1 modulates EMT and stemness genes expression in hypoxic glioblastoma
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DOI: 10.1002/ijc.31092
Abstract: Glioblastoma (GBM) is characterized by the presence of hypoxia, stemness and local invasiveness. We have earlier demonstrated that FAT1 promotes invasiveness, inflammation and upregulates HIF‐1α expression and its signaling in hypoxic GBM. Here, we have… read more here.
Keywords: stemness; emt stemness; fat1; expression ... See more keywords
Abstract 1258: A cholesterol metabolite can modulate neutrophil-derived extracellular vesicles to promote breast cancer cell epithelial to mesenchymal transition (EMT) and stemness
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DOI: 10.1158/1538-7445.am2024-1258
Abstract: Breast cancer is the second leading cause of cancer-related death in women, with mortality most often due to metastatic recurrence. Elevated cholesterol is associated with poor prognosis, with several potential mechanisms proposed. Work in murine… read more here.
Keywords: cancer; breast cancer; emt stemness; cancer cell ... See more keywords
Genistein Restricts the Epithelial Mesenchymal Transformation (EMT) and Stemness of Hepatocellular Carcinoma via Upregulating miR-1275 to Inhibit the EIF5A2/PI3K/Akt Pathway
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DOI: 10.3390/biology11101383
Abstract: Simple Summary Genistein is a natural phytoestrogen with various antitumor effects. Our study focused on exploring the mechanisms of microRNAs and genistein to inhibit the epithelial mesenchymal transformation (EMT) and stemness of hepatocellular carcinoma (HCC).… read more here.
Keywords: hcc; emt stemness; mir 1275;
GDF15 Contributes to Radioresistance by Mediating the EMT and Stemness of Breast Cancer Cells
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DOI: 10.3390/ijms231810911
Abstract: Radiotherapy is one of the conventional methods for the clinical treatment of breast cancer. However, radioresistance has an adverse effect on the prognosis of breast cancer patients after radiotherapy. In this study, using bioinformatic analysis… read more here.
Keywords: cancer; emt stemness; prognosis; breast cancer ... See more keywords