Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of β-Lactamases.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c09876
Abstract: The widespread design of covalent drugs has focused on crafting reactive groups of proper electrophilicity and positioning toward targeted amino-acid nucleophiles. We found that environmental electric fields projected onto a reactive chemical bond, an overlooked… read more here.
Keywords: covalent inhibition; protein electric; enable faster; fields enable ... See more keywords