Transient Directing Group Enabled Pd-catalyzed γ-C(sp3)-H Oxygenation of Alkyl Amines.
Sign Up to like & getrecommendations! Published in 2020 at "ACS catalysis"
DOI: 10.1021/acscatal.0c01310
Abstract: We report a general protocol for γ-C(sp3)-H acyloxylation and alkoxylation of free amines using 2-hydroxynicotinaldehyde as the transient directing group. In the presence of an electrophilic fluorinating bystanding oxidant and acetic acid, a wide range… read more here.
Keywords: directing group; catalyzed sp3; group enabled; transient directing ... See more keywords
Ligand Enabled Pd(II)-Catalyzed γ-C(sp3)-H Lactamization of Native Amides.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c10183
Abstract: γ-Lactams form important structural cores of a range of medicinally relevant natural products and clinical drugs, principal examples being the new generation of immunomodulatory imide drugs (IMiDs) and the brivaracetam family. Compared to conventional multistep… read more here.
Keywords: sp3 lactamization; enabled catalyzed; ligand enabled; catalyzed sp3 ... See more keywords