Bis(pinacolato)diboron‐Enabled Ni‐Catalyzed Reductive Arylation/Vinylation of Alkyl Electrophiles
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DOI: 10.1002/advs.202404301
Abstract: Herein, the use of economically and environmentally friendly bis(pinacolato)diboron (B2Pin2) is described as a non‐metallic reductant in mediating Ni‐catalyzed C(sp3)–C(sp2) reductive cross‐coupling of alkyl electrophiles with aryl/vinyl halides. This method exhibits excellent suitability for heteroaryl… read more here.
Keywords: enabled catalyzed; diboron enabled; alkyl electrophiles; pinacolato diboron ... See more keywords
Tropone-Enabled Pd-Catalyzed C(sp2)-H Functionalization of Phenylalanine: Switchable Access to Indoline and Olefinate.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c03211
Abstract: Herein, we report Pd-catalyzed and site-selective C(sp2)-H amination/olefination of phenylalanine. The transformation proceeds via a troponyl carbonyl-directed intramolecular C-N cyclization forming indoline scaffolds through C(sp2)-H activation with PIDA. In the absence of PIDA, ortho-C(sp2)-H olefination… read more here.
Keywords: enabled catalyzed; sp2; catalyzed sp2; phenylalanine ... See more keywords
Transient Directing Group Enabled Pd-catalyzed γ-C(sp3)-H Oxygenation of Alkyl Amines.
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DOI: 10.1021/acscatal.0c01310
Abstract: We report a general protocol for γ-C(sp3)-H acyloxylation and alkoxylation of free amines using 2-hydroxynicotinaldehyde as the transient directing group. In the presence of an electrophilic fluorinating bystanding oxidant and acetic acid, a wide range… read more here.
Keywords: directing group; catalyzed sp3; group enabled; transient directing ... See more keywords
Ligand Enabled Pd(II)-Catalyzed γ-C(sp3)-H Lactamization of Native Amides.
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DOI: 10.1021/jacs.1c10183
Abstract: γ-Lactams form important structural cores of a range of medicinally relevant natural products and clinical drugs, principal examples being the new generation of immunomodulatory imide drugs (IMiDs) and the brivaracetam family. Compared to conventional multistep… read more here.
Keywords: sp3 lactamization; enabled catalyzed; ligand enabled; catalyzed sp3 ... See more keywords
Electrochemistry-enabled Ir-catalyzed C-H/N-N bond activation facilitates [3+2] annulation of phenidones with propiolates.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d4cc03124e
Abstract: A mild and efficient [3+2] annulation of phenidones with propiolates has been developed to access N-substituted indole alkylamides, enabled by merging electrochemistry with iridium catalysis using an undivided cell at room temperature. The mechanistic studies… read more here.
Keywords: enabled catalyzed; phenidones propiolates; electrochemistry enabled; electrochemistry ... See more keywords
Amino Alcohol Ligand-enabled Ni-Catalyzed Regio- and Diastereoselective Dearomative Borylalkylation of Indoles
Sign Up to like & getrecommendations! Published in 2025 at "Organic Chemistry Frontiers"
DOI: 10.1039/d4qo02187h
Abstract: The transition-metal-catalyzed intermolecular three-component dearomative difunctionalization of indoles in a one-pot fashion remains largely unexplored. Herein, we present a novel Ni-catalyzed dearomative alkylborylation of indoles utilizing a ligand-enabled, directing group-assisted... read more here.
Keywords: enabled catalyzed; catalyzed regio; ligand enabled; ligand ... See more keywords