Ni-Catalyzed Regioselective Alkylarylation of Unactivated Alkenes in Amines Enabled by Cooperative Ligand Effects of Nitriles and Electron-Deficient Alkenes.
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DOI: 10.1021/jacs.4c12334
Abstract: We report a Ni-catalyzed vicinal alkylarylation of unactivated alkenes in γ,δ- and δ,ε-alkenylamines with aryl halides and alkylzinc reagents. The reaction is enabled by amine coordination and can use all primary, secondary, and tertiary amines.… read more here.
Keywords: unactivated alkenes; nitriles electron; electron deficient; enabled cooperative ... See more keywords
Redox-enabled cooperative catalysis by activating secondary alcohols using low-valent Zn complexes.
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DOI: 10.1039/d4cc03407d
Abstract: Inspired by nature's redox management in bioinorganic systems, we developed various Zn-complexes to catalyze a radical-mediated borrowing hydrogen process for producing β-disubstituted ketones. A diverse range of secondary alcohols, including fatty alcohols, terpenoids and steroid… read more here.
Keywords: catalysis activating; cooperative catalysis; enabled cooperative; activating secondary ... See more keywords
Chiral Bifunctional N, N, P-Ligand-Enabled Cooperative Cu Catalysis: One-Pot Two-Step Propargylic Substitution of Propargylic Alcohols
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DOI: 10.1039/d5qo00595g
Abstract: Propargyl moieties are important structural features that are ubiquitously found in numerous natural products and pharmaceutical molecules. Due to the high reaction barrier, copper-catalyzed enantioselective propargylation with propargylic alcohol has... read more here.
Keywords: cooperative catalysis; ligand enabled; catalysis one; bifunctional ligand ... See more keywords