Electrochemically Enabled Double C-H Activation of Amides: Chemoselective Synthesis of Polycyclic Isoquinolinones.
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DOI: 10.1021/acs.orglett.9b03682
Abstract: We developed an electrochemically enabled dehydrogenative annulation reaction of amides and alkynes for the synthesis of antitumor polycyclic isoquinolinones through a double C-H activation route. No external oxidant is required in this reaction, and electricity… read more here.
Keywords: polycyclic isoquinolinones; electrochemically enabled; double activation; enabled double ... See more keywords