Lewis Base Catalysis Enables the Activation of Alcohols by means of Chloroformates as Phosgene Substitutes
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DOI: 10.1002/cctc.202001175
Abstract: Nucleophilic substitutions (SN) are typically promoted by acid chlorides as sacrificial reagents to improve the thermodynamic driving force and lower kinetic barriers. However, the cheapest acid chloride phosgene (COCl2) is a highly toxic gas. Against… read more here.
Keywords: catalysis enables; enables activation; base catalysis; lewis base ... See more keywords