A Chemoselective α-Oxytriflation Enables the Direct Asymmetric Arylation of Amides
Sign Up to like & getrecommendations! Published in 2019 at "Chem"
DOI: 10.1016/j.chempr.2019.05.006
Abstract: Summary Until recently, the direct oxidative oxysulfonylation of carbonyl compounds was limited to ketones. Here, we report the first direct oxytriflation of simple, non-activated amides. Amide umpolung with triflic anhydride and pyridine-N-oxide in the absence… read more here.
Keywords: asymmetric arylation; enables direct; arylation; oxytriflation enables ... See more keywords
Aminoalkylation of [1.1.1]Propellane Enables Direct Access to High-Value 3-Alkylbicyclo[1.1.1]pentan-1-amines.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02426
Abstract: Bicyclo[1.1.1]pentanes are effective bioisoteres for aromatic rings, tert-butyl groups, and alkynes. Here we report the first method to synthesize 3-alkylbicyclo[1.1.1]pentan-1-amines directly from [1.1.1]propellane via sequential addition of magnesium amides and alkyl electrophiles. The mild reaction… read more here.
Keywords: aminoalkylation propellane; pentan amines; direct access; enables direct ... See more keywords
Organoelectrocatalysis Enables Direct Cyclopropanation of Methylene Compounds.
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DOI: 10.1021/jacs.1c12762
Abstract: Cyclopropane is a prevalent structural unit in natural products and bioactive compounds. While the transition metal-catalyzed alkene cyclopropanation of functionalized compounds such as α-diazocarbonyl derivatives has been well established and provides straightforward access to cyclopropanes,… read more here.
Keywords: enables direct; direct cyclopropanation; methylene compounds; cyclopropanation ... See more keywords