Characterization of an Exceptional Fungal Mutant Enables the Discovery of the Specific Regulator of a Silent PKS-NRPS Hybrid Biosynthetic Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03550
Abstract: Filamentous fungi produce a great variety of bioactive secondary metabolites essential for their biotic interactions. Here, we characterized an exceptional Trichoderma mutant overproducing harzianic acids (HAs) with exclusively highly antifungal activity against numerous fungi from… read more here.
Keywords: fungal mutant; enables discovery; mutant; characterization exceptional ... See more keywords
Enhanced Validation of Antibodies Enables the Discovery of Missing Proteins
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.0c00486
Abstract: The localization of proteins at a tissue- or cell-type-specific level is tightly linked to the protein function. To better understand each protein’s role in cellular systems, spatial information constitutes an important complement to quantitative data.… read more here.
Keywords: missing proteins; antibodies enables; enhanced validation; validation antibodies ... See more keywords
Abstract 3755: AmpliconSuite enables discovery of extrachromosomal DNA in tumor genomes
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3755
Abstract: Focal amplifications in the cancer genome, particularly extrachromosomal DNA (ecDNA) amplifications, are a pivotal event in cancer progression across diverse cancer contexts. These megabase-scale circular structures arise when DNA breaks off chromosomes, accumulating hundreds of… read more here.
Keywords: cancer; tumor; extrachromosomal dna; enables discovery ... See more keywords