Angiotensin II regulates δ-ENaC in human umbilical vein endothelial cells.
Sign Up to like & getrecommendations! Published in 2018 at "Microvascular research"
DOI: 10.1016/j.mvr.2017.10.001
Abstract: The amiloride-sensitive epithelial sodium channel (ENaC) has been characterized in a variety of non-epithelial tissues. In the current study we sought to understand the effect of angiotensin II on δ ENaC function using human umbilical… read more here.
Keywords: enac; vein endothelial; human umbilical; endothelial cells ... See more keywords
Changes in plasma aldosterone and electrolytes levels, kidney epithelial sodium channel (ENaC) and blood pressure in normotensive WKY and hypertensive SHR rats following gonadectomy and chronic testosterone treatment
Sign Up to like & getrecommendations! Published in 2017 at "Steroids"
DOI: 10.1016/j.steroids.2017.09.008
Abstract: HighlightsTestosterone causes MAP to increase in females.Testosterone induces decreased in aldosterone, sodium (Na+) and osmolality levels in females.Expression and distribution of &agr;, &bgr; and &ggr;‐ENaC in kidneys in females decreased under testosterone influence.Orchidectomy decreases MAP… read more here.
Keywords: shr rats; plasma aldosterone; enac; testosterone ... See more keywords
Shear force sensing of epithelial Na+ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1911243117
Abstract: Significance The ability to sense mechanical forces is essential for all living organisms. Extracellular tethers have been proposed to mediate mechanical activation of channels belonging to the epithelial Na+ channel (ENaC)/degenerin protein family. The nature… read more here.
Keywords: blood pressure; force; glycosylated asparagines; enac ... See more keywords
The role of distal tubule and collecting duct sodium reabsorption in sunitinib-induced hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000001650
Abstract: Objective: Antiangiogenic receptor tyrosine kinase inhibitors (RTKI) induce arterial hypertension which may limit their use. Renal fractional sodium excretion (FENa) is reduced in early RTKI-induced hypertension, whereas fractional lithium excretion is unaltered. Therefore, we tested… read more here.
Keywords: enac; induced hypertension; sodium reabsorption; sunitinib ... See more keywords
Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung
Sign Up to like & getrecommendations! Published in 2018 at "Thorax"
DOI: 10.1136/thoraxjnl-2017-210670
Abstract: Introduction Loss of the cystic fibrosis transmembrane conductance regulator in cystic fibrosis (CF) leads to hyperabsorption of sodium and fluid from the airway due to upregulation of the epithelial sodium channel (ENaC). Thickened mucus and… read more here.
Keywords: cystic fibrosis; mouse lung; enac; effective silencing ... See more keywords
Mice lacking gamma ENaC palmitoylation sites maintain amiloride/benzamil-sensitive Na+ transport in vivo, despite markedly reduced open probability of typical ENaC-like channels.
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5729916
Abstract: Background: Epithelial Na+ channels (ENaCs) play a major role in controlling extracellular fluid volume and electrolyte homeostasis by facilitating absorption of Na+ across transporting epithelia, such as the kidney and distal colon. ENaCs are heterotrimeric… read more here.
Keywords: enac; physiology; palmitoylation; enac c33a ... See more keywords
Role of paraoxonase 3 (PON3) in regulating ENaC-mediated sodium transport in distal nephron
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731198
Abstract: PON3 is expressed in the aldosterone-sensitive distal nephron, where ENaC plays an essential role in maintaining Na+/K+ homeostasis in the kidney. The aims of our study were to determine the physiological roles of PON3 in… read more here.
Keywords: distal nephron; enac; role; physiology ... See more keywords
Rare Single-Nucleotide Variants that Impact Human ENaC Function
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733424
Abstract: While single-nucleotide variants (SNV) in ENaC coding region occur throughout functional domains, only a few SNVs exhibit pathophysiological phenotypes with mendelian inheritance. Since a SNV that alters ENaC’s ability to sense extracellular Na⁺ has been… read more here.
Keywords: function; enac; single nucleotide; physiology ... See more keywords
Cellular and Molecular Mechanisms Regulating the Normal Physiological Function of ENaC in Salt-Sensitive Hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734102
Abstract: High blood pressure is a significant risk factor for cardiovascular disease. Many details about the molecular mechanisms that regulate blood pressure are unknown. The Epithelial Na+ Channel (ENaC) is the final arbiter of Na+ excretion… read more here.
Keywords: physiology; ckii; blood pressure; enac ... See more keywords
Defining corticosteroid-regulated sodium transport within the distal nephron
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735058
Abstract: The aldosterone (ALDO)-sensitive distal nephron is typically defined as: the late distal convoluted tubule (DCT2), connecting tubule (CNT) and cortical collecting duct (CCD). ALDO-sensitivity is defined by 11βHSD2 (11β) activity (which inactivates corticosterone, CORT); mineralocorticoid… read more here.
Keywords: distal nephron; enac; cnt; physiology ... See more keywords
In mouse kidney endogenous transmembrane serine protease 2 (TMPRSS2) contributes to proteolytic processing and activation of the epithelial sodium channel (ENaC)
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5765008
Abstract: Regulation of ENaC in the distal nephron is essential for sodium homeostasis and blood pressure control. A unique feature of ENaC is its complex proteolytic processing leading to channel activation due to release of inhibitory… read more here.
Keywords: channel; enac; sodium; physiology ... See more keywords