Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14387
Abstract: The NPHS2 gene, encoding the slit diaphragm protein podocin, accounts for genetic and sporadic forms of nephrotic syndrome (NS). Patients with NS often present symptoms of volume retention, such as oedema formation or hypertension. The… read more here.
Keywords: cathepsin; enac activity; hypertension; retention ... See more keywords
Palmitate Stimulates the Epithelial Sodium Channel by Elevating Intracellular Calcium, Reactive Oxygen Species, and Phosphoinositide 3-Kinase Activity
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/7560610
Abstract: Previous studies indicate that the epithelial sodium channel (ENaC) in the kidney is upregulated in diabetes mellitus. Here, we show that ENaC single-channel activity in distal nephron cells was significantly increased by palmitate, a free… read more here.
Keywords: palmitate; channel; enac activity; intracellular ca2 ... See more keywords
Sexual dimorphism in obesity-associated endothelial ENaC activity and stiffening in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1210/endocr/bqz002
Abstract: Obesity and insulin resistance stiffen the vasculature with females appearing to be more adversely affected. As augmented arterial stiffness is an independent predictor of cardiovascular disease (CVD), the increased predisposition of obese and insulin-resistant women… read more here.
Keywords: dimorphism obesity; obesity associated; enac activity; obesity ... See more keywords
Mesenchymal stem cell-conditioned medium rescues LPS-impaired ENaC activity in mouse trachea via WNK4 pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Current pharmaceutical design"
DOI: 10.2174/1381612826666200131141732
Abstract: BACKGROUND Airway epithelium plays an essential role in maintaining the homeostasis and function of respiratory system as the first line of host defense. Of note, epithelial sodium channel (ENaC) is one of the victims of… read more here.
Keywords: conditioned medium; airway injury; enac activity; activity ... See more keywords
Optogenetic Control of PIP2 Interactions Shaping ENaC Activity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073884
Abstract: The activity of the epithelial Na+ Channel (ENaC) is strongly dependent on the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 binds two distinct cationic clusters within the N termini of β- and γ-ENaC subunits (βN1 and… read more here.
Keywords: corona green; activity; pip2 depletion; enac activity ... See more keywords