Enantio- and Regioselective CuH-Catalyzed Conjugate Reduction of Yne-Allenones.
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DOI: 10.1021/acs.orglett.1c00892
Abstract: A new asymmetric catalytic conjugate reduction of yne-allenones to synthesize enantioenriched cyclobuta[a]naphthalen-4(2H)-ones has been established that uses copper-bisphosphine complexes as catalysts and gives excellent regio- and enantioselectivities (≥99% ee) in most cases. This protocol tolerates… read more here.
Keywords: enantio regioselective; yne allenones; reduction yne; conjugate reduction ... See more keywords
Nickel-Catalyzed Regio- and Enantioselective Hydroamination of Unactivated Alkenes Using Carbonyl Directing Groups.
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DOI: 10.1021/jacs.2c02343
Abstract: The asymmetric addition of an N-H bond to various alkenes via a direct catalytic method is a powerful way of synthesizing value-added chiral amines. Therefore, the enantio- and regioselective hydroamination of unactivated alkenes remains an… read more here.
Keywords: enantio regioselective; hydroamination unactivated; catalyzed regio; nickel catalyzed ... See more keywords
Enantio- and Regioselective Ni-Catalyzed para-C-H Alkylation of Pyridines with Styrenes via Intermolecular Hydroarylation.
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DOI: 10.1021/jacs.2c04043
Abstract: Direct asymmetric functionalization of the pyridyl C-H bond represents a longstanding challenge in organic chemistry. We herein describe the first enantioselective para-C-H activation of pyridines through the use of a Ni-Al bimetallic catalyst system and… read more here.
Keywords: intermolecular hydroarylation; enantio regioselective; regioselective catalyzed; catalyzed para ... See more keywords