Highly stereoselective and enantiodivergent synthesis of cyclopropylphosphonates with engineered carbene transferases
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DOI: 10.1039/d2sc01965e
Abstract: Organophosphonate compounds have represented a rich source of biologically active compounds, including enzyme inhibitors, antibiotics, and antimalarial agents. Here, we report the development of a highly stereoselective strategy for olefin cyclopropanation in the presence of… read more here.
Keywords: enantiodivergent synthesis; stereoselective enantiodivergent; carbene; highly stereoselective ... See more keywords
Enantiodivergent Synthesis of Both PAMPO Enantiomers Using l-Menthyl Chloroacetate and Stereomutation at P in Classical Quaternisation Reactions
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DOI: 10.1055/s-0039-1691531
Abstract: A practical protocol for efficient synthesis of both PAMPO enantiomers as well as related functionalised P-stereogenic phosphine oxides in 1–3 steps from effectively resolved (S P)- l -menthyl o-anisyl-(phenyl)phosphinylacetate has been developed. Examples of non-stereoselective… read more here.
Keywords: synthesis pampo; enantiodivergent synthesis; quaternisation; synthesis ... See more keywords