Articles with "enantiodivergent synthesis" as a keyword



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Highly stereoselective and enantiodivergent synthesis of cyclopropylphosphonates with engineered carbene transferases

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Published in 2022 at "Chemical Science"

DOI: 10.1039/d2sc01965e

Abstract: Organophosphonate compounds have represented a rich source of biologically active compounds, including enzyme inhibitors, antibiotics, and antimalarial agents. Here, we report the development of a highly stereoselective strategy for olefin cyclopropanation in the presence of… read more here.

Keywords: enantiodivergent synthesis; stereoselective enantiodivergent; carbene; highly stereoselective ... See more keywords
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Enantiodivergent Synthesis of Both PAMPO Enantiomers Using l-Menthyl Chloroacetate and Stereomutation at P in Classical Quaternisation Reactions

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Published in 2019 at "Synthesis"

DOI: 10.1055/s-0039-1691531

Abstract: A practical protocol for efficient synthesis of both PAMPO enantiomers as well as related functionalised P-stereogenic phosphine oxides in 1–3 steps from effectively resolved (S P)- l -menthyl o-anisyl­-(phenyl)phosphinylacetate has been developed. Examples of non-stereo­selective… read more here.

Keywords: synthesis pampo; enantiodivergent synthesis; quaternisation; synthesis ... See more keywords