Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32572-2
Abstract: Traumatic brain injury (TBI) elevates Abeta (Aβ) peptides in the brain and cerebral spinal fluid. Aβ peptides are amphipathic molecules that can modulate membrane mechanics. Because the mechanosensitive cation channel PIEZO1 is gated by membrane… read more here.
Keywords: piezo1; shear stress; stress; fluid shear ... See more keywords
Inhibition of amyloid Aβ aggregation by high pressures or specific d-enantiomeric peptides.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc01458b
Abstract: Pressure can shift the polymer-monomer equilibrium of Aβ, increasing pressure first leads to a release of Aβ-monomers, surprisingly at pressures higher than 180 MPa repolymerization is induced. By high pressure NMR spectroscopy, differences of partial… read more here.
Keywords: pressure; aggregation high; inhibition amyloid; high pressures ... See more keywords