A hierarchical screening approach to enantiomeric separation.
Sign Up to like & getrecommendations! Published in 2017 at "Chirality"
DOI: 10.1002/chir.22694
Abstract: The screening of a number of chiral stationary phases (CSPs) with different modifiers in supercritical fluid chromatography to find a chromatographic method for separation of enantiomers can be time-consuming. Computational methods for data analysis were… read more here.
Keywords: approach enantiomeric; screening approach; enantiomeric separation; separation ... See more keywords
Enantiomeric separation of Novel Psychoactive Substances by capillary electrophoresis using (+)-18-crown-6-tetracarboxylic acid as chiral selector.
Sign Up to like & getrecommendations! Published in 2018 at "Chirality"
DOI: 10.1002/chir.22981
Abstract: In the recent years, hundreds of Novel Psychoactive Substances (NPS) have entered both the European and the global drug market. These drugs, which are mainly used for recreational matters, have caused serious social problems. Every… read more here.
Keywords: psychoactive substances; crown tetracarboxylic; enantiomeric separation; tetracarboxylic acid ... See more keywords
Preparation and chromatographic performance of chiral peptide-based stationary phases for enantiomeric separation.
Sign Up to like & getrecommendations! Published in 2023 at "Chirality"
DOI: 10.1002/chir.23564
Abstract: This study presents the development of three new chiral stationary phases. They are based on silica modified with peptides containing phenylalanine and proline. Successful analyses and characterizations were conducted using Fourier transform infrared spectra, elemental… read more here.
Keywords: peptide based; stationary phases; enantiomeric separation; performance ... See more keywords
Enantiomeric separation and quantification of R/S-amphetamine in serum using semi-automated liquid-liquid extraction and ultra-high performance supercritical fluid chromatography-tandem mass spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2879
Abstract: The amphetamine molecule contains a chiral center and its enantiomers exhibit differences in pharmacological effects, with the S-enantiomer mediating most of the central nervous system stimulating activity. The majority of prescribed amphetamine consists of the… read more here.
Keywords: quantification amphetamine; enantiomeric separation; amphetamine; separation quantification ... See more keywords
Liquid Chromatographic Enantiomeric Separation of Chiral Aliphatic Amines Using 2-Hydroxynaphthaldehyde as a Derivatizing Agent on Polysaccharide-Derived Chiral Stationary Phases
Sign Up to like & getrecommendations! Published in 2018 at "Chromatographia"
DOI: 10.1007/s10337-018-3560-y
Abstract: A new liquid chromatographic enantiomer separation of chiral amines as 2-hydroxynaphthaldimine derivatives on several coated and immobilized chiral stationary phases (CSPs) derived from polysaccharides is described. 2-Hydroxynaphthaldehyde was introduced as a derivatizing agent for the… read more here.
Keywords: enantiomeric separation; separation; chiral aliphatic; aliphatic amines ... See more keywords
Use of polysaccharide-based chiral columns: enantiomeric separation of seven pairs of abused drugs by high-performance liquid chromatography–mass spectrometry
Sign Up to like & getrecommendations! Published in 2018 at "Forensic Toxicology"
DOI: 10.1007/s11419-018-0453-6
Abstract: The International Federation of Horse Racing Authorities has published a list of prohibited substances [1], which includes corticosteroids [2, 3], anabolic steroids [4–7], diuretics [8, 9], central nervous system stimulants [10], β-adrenergic receptor blocking agents… read more here.
Keywords: enantiomeric separation; drug; separation; polysaccharide based ... See more keywords
Enantiomeric separation and enantioselective determination of some representive non-steroidal anti-inflammatory drug enantiomers in fish tissues by using chiral liquid chromatography coupled with tandem mass spectrometry
Sign Up to like & getrecommendations! Published in 2020 at "Microchemical Journal"
DOI: 10.1016/j.microc.2019.104511
Abstract: Abstract In this work, enantiomeric separation of nine non-steroidal anti-inflammatory drugs including ibuprofen, indoprofen, pranoprofen, flurbiprofen, ketoprofen, carprofen, naproxen, loxoprofen and etodolac was investigated by HPLC combining with four polysaccharide based chiral stationary phases (Chiralpak… read more here.
Keywords: enantiomers fish; enantiomeric separation; fish tissues; steroidal anti ... See more keywords
Engineering UiO-68-Typed Homochiral Metal-Organic Frameworks for the Enantiomeric Separation of Fmoc-AAs and Mechanism Study.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c01735
Abstract: Homochiral metal-organic frameworks (HMOFs) have been widely investigated in the application of enantiomeric separation. Nonetheless, it remains a significant challenge to explore the effect of multiple weak interactions between HMOF adsorbents and chiral adsorbates on… read more here.
Keywords: homochiral metal; fmoc; enantiomeric separation; separation ... See more keywords
Enhancing Enantiomeric Separation with Strain: The Case of Serine on Cu(531).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b01216
Abstract: Serine has two enantiomers, d and l, which exhibit identical physical and chemical properties but have dramatically different physiological effects. For the pharmaceutical industry, it is very important to be able to separate both enantiomers.… read more here.
Keywords: separation strain; enantiomeric separation; enhancing enantiomeric; serine ... See more keywords
Enantiomeric separation and simulation study of eight anticholinergic drugs on an immobilized polysaccharide-based chiral stationary phase by HPLC
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj00685g
Abstract: The enantiomeric separation of eight anticholinergic drugs was first systematically examined on a derivative polysaccharide chiral stationary phase (CSP), i.e. Chiralpak ID in the normal phase mode. Except for scopolamine hydrobromide and benzhexol hydrochloride, the… read more here.
Keywords: phase; enantiomeric separation; chiral stationary; anticholinergic drugs ... See more keywords
New Discoveries in Enantiomeric Separation of Racemic Tofisopam
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemistry"
DOI: 10.1155/2019/4980792
Abstract: Resolution process of tofisopam has been re-evaluated now based on our new investigations. Originally, it was carried out in the water-chloroform system, where the intermediate salt of high diastereomeric excess was described as (R)-TOF·(R,R)-DBTA·(H2O)3. Opposed… read more here.
Keywords: resolution; new discoveries; tof dbta; discoveries enantiomeric ... See more keywords