Ultrasound‐Promoted Enantioselective Decarboxylative Protonation of α‐Aminomalonate Hemiesters by Chiral Squaramides: A Practical Approach to Both Enantiomers of α‐Amino Esters
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DOI: 10.1002/ejoc.201700786
Abstract: Ultrasound promoted enantioselelctive decarboxylative protonation reaction of α-aminomalonate hemiesters 1 in the presence of chiral cinchona-derived squaramide Bronsted bases under mild conditions afforded both the (S) and (R) enantiomers of α-amino acid derivatives 2 in… read more here.
Keywords: enantiomers amino; aminomalonate hemiesters; ultrasound promoted; decarboxylative protonation ... See more keywords
Synthesis of Four Enantiomers of (1-Amino-3-Hydroxypropane-1,3-Diyl)Diphosphonic Acid as Diphosphonate Analogues of 4-Hydroxyglutamic Acid
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DOI: 10.3390/molecules27092699
Abstract: All the enantiomers of (1-amino-3-hydroxypropane-1,3-diyl)diphosphonic acid, newly design phosphonate analogues of 4-hydroxyglutamic acids, were obtained. The synthetic strategy involved Abramov reactions of diethyl (R)- and (S)-1-(N-Boc-amino)-3-oxopropylphosphonates with diethyl phosphite, separation of diastereoisomeric [1-(N-Boc-amino)-3-hydroxypropane-1,3-diyl]diphosphonates as O-protected… read more here.
Keywords: amino hydroxypropane; acid; hydroxypropane diyl; enantiomers amino ... See more keywords