A convenient synthesis of enantiopure (4aS,7aR)-1,4,4a,7a-tetrahydrocyclopenta[c]pyran-3,7-dione
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DOI: 10.1016/j.mencom.2020.01.003
Abstract: The title compound, as the new chiral building block for bioactive cyclopentenones, was prepared in 8 steps with 15% overall yield. The key steps involve selective homologation in intermediate [(1S,2R,5R)-5-trimethysilylcyclopent-3-ene- 1,2-diyl]dimethanol by regioselective silylation followed… read more here.
Keywords: 7ar tetrahydrocyclopenta; convenient synthesis; enantiopure 4as; synthesis enantiopure ... See more keywords