Cooperative Palladium/Brønsted Acid Catalysis toward the Highly Enantioselective Allenylation of β-Keto Esters.
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DOI: 10.1021/acs.orglett.2c00179
Abstract: We report the first enantioselective allenylation of Pd enolates enabled by cooperative Pd/Brønsted acid catalysis employing β-keto esters and propargyl alcohols. The enantioselectivity originates solely from an in-situ-generated chiral metal enolate in an open transition… read more here.
Keywords: acid catalysis; nsted acid; keto esters; enantioselective allenylation ... See more keywords