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   Articles with "enantioselective allylic" as a keyword



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Ligand-Dependent Regiodivergent Enantioselective Allylic Alkylations of α-Trifluoromethylated Ketones.

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recommendations! Published in 2021 at "Organic letters"

DOI: 10.1021/acs.orglett.1c00329

Abstract: The asymmetric introduction of the CF3 unit is a powerful tool for modifying pharmacokinetic properties and slowing metabolic degradation in medicinal chemistry. A catalytic and enantioselective addition of α-CF3 enolates allows for expeditious access to… read more here.

Keywords: alkylations trifluoromethylated; regiodivergent enantioselective; dependent regiodivergent; enantioselective allylic ... See more keywords
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Ni-Catalyzed Enantioselective Allylic Alkylation of H-Phosphinates.

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recommendations! Published in 2021 at "Organic letters"

DOI: 10.1021/acs.orglett.1c02986

Abstract: The asymmetric synthesis of P-stereogenic phosphinates through allylic alkylation of H-phosphinates has been developed. With H-phosphinates and allylic acetates as the starting materials, a variety of allylic P-chiral phosphinates were accessed in high enantioselectivities of… read more here.

Keywords: alkylation phosphinates; enantioselective allylic; catalyzed enantioselective; allylic alkylation ... See more keywords
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Rh-Catalyzed Regio- and Enantioselective Allylic Phosphinylation.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c00239

Abstract: Transition-metal-catalyzed branched and enantioselective allylic substitution of monosubstituted precursors with carbon, nitrogen, oxygen, sulfur, and fluoride nucleophiles has been well-established. However, such a selective carbon-phosphorus bond formation has not been realized probably due to the… read more here.

Keywords: phosphine; catalyzed regio; allylic phosphinylation; enantioselective allylic ... See more keywords
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Cobalt-Catalyzed Regio- and Enantioselective Allylic Amination.

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recommendations! Published in 2019 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.9b06035

Abstract: The first earth-abundant cobalt-catalyzed highly branched- and enantioselective allylic amination of racemic branched allylic car-bonates bearing alkyl groups with both aromatic and aliphatic amines have been developed. The process allows rapid access of allylic amines… read more here.

Keywords: catalyzed regio; enantioselective allylic; allylic amination; cobalt catalyzed ... See more keywords
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Cu-catalyzed enantioselective allylic alkylation with organolithium reagents

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recommendations! Published in 2017 at "Nature Protocols"

DOI: 10.1038/nprot.2016.179

Abstract: This protocol describes a method for the catalytic enantioselective synthesis of tertiary and quaternary carbon stereogenic centers, which are widely present in pharmaceutical and natural products. The method is based on the direct reaction between… read more here.

Keywords: organolithium reagents; allylic alkylation; catalyzed enantioselective; enantioselective allylic ... See more keywords
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Pd-Catalyzed regio- and enantioselective allylic substitution with 2-pyridones.

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recommendations! Published in 2019 at "Chemical communications"

DOI: 10.1039/c9cc07482a

Abstract: An efficient method for the asymmetric synthesis of N-substituted 2-pyridones via Pd-catalyzed regio- and enantioselective allylic substitution of hydroxyl-containing allylic carbonates with 2-pyridones has been developed. By using a palladium complex in situ generated from… read more here.

Keywords: catalyzed regio; regio enantioselective; substitution pyridones; enantioselective allylic ... See more keywords

Organocatalytic enantioselective allylic alkylation of α-aryl γ-lactones: an approach to densely functionalized quaternary stereocentres.

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recommendations! Published in 2020 at "Chemical communications"

DOI: 10.1039/d0cc02058c

Abstract: The asymmetric allylic alkylation (AAA) of α-aryl γ-lactones involving the activation of Morita-Baylis-Hillman (MBH) carbonates by an original chiral Lewis base is reported. A wide range of γ-lactones bearing a quaternary stereocentre was thus obtained… read more here.

Keywords: organocatalytic enantioselective; aryl lactones; allylic alkylation; enantioselective allylic ... See more keywords