Chiral π-Cu(II) Catalysts for the Enantioselective α-Amination of N-Acyl-3,5-dimethylpyrazoles.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03249
Abstract: We report the highly enantioselective α-amination of N-acyl-3,5-dimethylpyrazoles with dialkyl azodicarboxylates, catalyzed by in situ generated π-Cu(II) complexes that consist of Cu(OTf)2 and N-(5H-dibenzo[a,d][7]annulen-5-yl)-l-alanine-derived amides, to give the corresponding products as d-α-amino acid derivatives (up… read more here.
Keywords: chiral catalysts; acyl dimethylpyrazoles; amination acyl; enantioselective amination ... See more keywords
Enantioselective α-Amination of Acyclic 1,3-Dicarbonyls Catalyzed by N-Heterocyclic Carbene.
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DOI: 10.1021/acs.orglett.9b04232
Abstract: Herein, we describe a method for the catalytic enantioselective α-amination of α-substituted acyclic 1,3-ketoamides and 1,3-amidoesters that affords the products possessing N-substituted quaternary stereocenters with a chiral N-heterocyclic carbene (NHC). The reaction is based on… read more here.
Keywords: amination acyclic; acyclic dicarbonyls; enantioselective amination; heterocyclic carbene ... See more keywords
Direct catalytic enantioselective amination of ketones for the formation of tri- and tetrasubstituted stereocenters† †Electronic supplementary information (ESI) available: Experimental details, and characterization data. See DOI: 10.1039/c8sc00147b
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Science"
DOI: 10.1039/c8sc00147b
Abstract: A Zn–ProPhenol catalyzed direct amination of α-branched and unbranched ketones produces α-amino carbonyl and β-amino alcohol products. read more here.
Keywords: catalytic enantioselective; direct catalytic; ketones formation; amination ketones ... See more keywords