Enantioselective α-chlorination of β-keto esters and amides catalyzed by chiral imidodiphosphoric acids
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DOI: 10.1016/j.tetlet.2018.05.024
Abstract: Abstract Chiral imidodiphosphoric acids were employed as catalysts for the enantioselective α-chlorination of β-keto esters and amides using NCS as the chlorine source, providing a series of optically active products with good to high enantioselectivities… read more here.
Keywords: chiral imidodiphosphoric; chlorination; chlorination keto; enantioselective chlorination ... See more keywords
Enantioselective α-Chlorination Reactions of in Situ Generated C1 Ammonium Enolates under Base-Free Conditions
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DOI: 10.1021/acs.orglett.1c02256
Abstract: The asymmetric α-chlorination of activated aryl acetic acid esters can be carried out with high levels of enantioselectivities utilizing commercially available isothiourea catalysts under base-free conditions. The reaction, which proceeds via the in situ formation… read more here.
Keywords: free conditions; base free; enantioselective chlorination; ammonium enolates ... See more keywords