Organocatalytic Enantioselective Construction of Spiroketal Lactones Bearing Axial and Central Chirality via an Asymmetric Domino Reaction.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00845
Abstract: The catalytic asymmetric synthesis of chiral compounds with multiple stereogenic elements via a single catalytic process is challenging. This paper proposes a domino asymmetric electrophilic halocyclization strategy for constructing heterocycloalkenyl atropisomeric spiroketal lactones. A single… read more here.
Keywords: spiroketal lactones; construction spiroketal; enantioselective construction; domino ... See more keywords
Highly Enantioselective Construction of Dihydrooxazines via Pd-Catalyzed Asymmetric Carboetherification.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04123
Abstract: A straightforward synthesis of highly enantioenriched 5,6-dihydro-4H-1,2-oxazines is realized by Pd-catalyzed asymmetric carboetherification of γ,δ-alkenyl oximes with (hetero)aryl and alkenyl halides in the presence of a commercially available bisphosphine ligand. The enantioenriched products can be… read more here.
Keywords: catalyzed asymmetric; asymmetric carboetherification; enantioselective construction; highly enantioselective ... See more keywords
Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15489
Abstract: The axially chiral arylquinazolinone acts as a privileged structural scaffold, which is present in a large number of natural products and biologically active compounds as well as in chiral ligands. However, a direct catalytic enantioselective… read more here.
Keywords: nsted acid; enantioselective construction; catalysed enantioselective; axially chiral ... See more keywords
Enantioselective construction of quaternary tetrahydropyridines by palladium-catalyzed vinylborylation of alkenes.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc01488k
Abstract: Here, the highly enantioselective construction of 3,3-disubstituted tetrahydropyridines via Pd(0)-catalyzed asymmetric vinylborylation of (Z)-1-iodo-dienes and B2pin2 in the presence of a (S)-p-CF3-BnPHOX ligand is reported. This process is supposed to be initiated by oxidative addition… read more here.
Keywords: tetrahydropyridines palladium; construction; enantioselective construction; construction quaternary ... See more keywords
Enantioselective Construction of Dihydropyranone-Fused Indoles by [3+3] Annulation of in Situ-Derived Indolin-3-ones and Unsaturated Carboxylic Ester
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00377a
Abstract: We develop a N-heterocyclic carbene (NHC) and base-mediated [3+3] annulation reaction of the unsaturated carboxylic ester and sulfonium salts for the rapid and direct access to the enantioselective dihydropyrano[3,2-b]indoles. Easily... read more here.
Keywords: enantioselective construction; annulation; dihydropyranone fused; construction dihydropyranone ... See more keywords