Enantioselective Copper-Catalyzed Electrophilic Dearomative Azidation of β-Naphthols.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02604
Abstract: The first example of copper-catalyzed enantioselective dearomative azidation of β-naphthols using a readily available N3-transfer reagent is reported. A series of 2-hydroxy-1-naphthamides bearing a complex N-substituent were converted to the corresponding products in high yields… read more here.
Keywords: dearomative azidation; enantioselective copper; azidation naphthols; copper catalyzed ... See more keywords
Enantioselective Copper-Catalyzed sp2/sp3 Diborylation of 1-Chloro-1-Trifluoromethylalkenes
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DOI: 10.1021/acscentsci.2c00339
Abstract: Fluorine-containing organoboron compounds have emerged as novel building blocks in chemical synthesis; among them, fluorinated sp2/sp3 diborylated compounds are particularly appealing, since they might undergo chemoselective and diversified transformations of different C–B bonds with fluorinated… read more here.
Keywords: sp2 sp3; chloro trifluoromethylalkenes; enantioselective copper; catalyzed sp2 ... See more keywords
Enantioselective Copper-Catalyzed Borylative Amidation of Allenes.
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DOI: 10.1021/jacs.2c10507
Abstract: An approach for the copper-catalyzed synthesis of enantioenriched amides bearing an α-stereogenic center is disclosed. This method involves the addition of an allyl copper species to an isocyanate and allows access to α-substituted chiral amides… read more here.
Keywords: copper; borylative amidation; enantioselective copper; catalyzed borylative ... See more keywords
Enantioselective Copper-Catalyzed Fukuyama Indole Synthesis from 2-Vinylphenyl Isocyanides.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c01667
Abstract: Enantioenriched chiral indoles are of high interest for the pharmaceutical and agrochemical industries. Herein, we present an asymmetric Fukuyama indole synthesis through a mild and efficient radical cascade reaction to access 2-fluoroalkylated 3-(α-cyanobenzylated) indoles by… read more here.
Keywords: indole synthesis; fukuyama indole; synthesis; enantioselective copper ... See more keywords