Enantioselective Copper-Catalyzed N-H Insertion Reaction of Pyrazoles and α-Diazo Phosphates.
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DOI: 10.1021/acs.orglett.5c03859
Abstract: Asymmetric N-H insertion reaction provides a streamlined process for accessing N-alkylated pyrazoles and their derivatives. However, the enantioselective N-H insertion reaction of aromatic heterocycles with diazo compounds represents a long-standing challenge. Herein, we report a… read more here.
Keywords: reaction; copper catalyzed; insertion reaction; enantioselective copper ... See more keywords
Enantioselective Copper-Catalyzed Electrophilic Dearomative Azidation of β-Naphthols.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02604
Abstract: The first example of copper-catalyzed enantioselective dearomative azidation of β-naphthols using a readily available N3-transfer reagent is reported. A series of 2-hydroxy-1-naphthamides bearing a complex N-substituent were converted to the corresponding products in high yields… read more here.
Keywords: dearomative azidation; enantioselective copper; azidation naphthols; copper catalyzed ... See more keywords
Enantioselective Copper-Catalyzed sp2/sp3 Diborylation of 1-Chloro-1-Trifluoromethylalkenes
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DOI: 10.1021/acscentsci.2c00339
Abstract: Fluorine-containing organoboron compounds have emerged as novel building blocks in chemical synthesis; among them, fluorinated sp2/sp3 diborylated compounds are particularly appealing, since they might undergo chemoselective and diversified transformations of different C–B bonds with fluorinated… read more here.
Keywords: sp2 sp3; chloro trifluoromethylalkenes; enantioselective copper; catalyzed sp2 ... See more keywords
Enantioselective Copper-Catalyzed Borylative Amidation of Allenes.
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DOI: 10.1021/jacs.2c10507
Abstract: An approach for the copper-catalyzed synthesis of enantioenriched amides bearing an α-stereogenic center is disclosed. This method involves the addition of an allyl copper species to an isocyanate and allows access to α-substituted chiral amides… read more here.
Keywords: copper; borylative amidation; enantioselective copper; catalyzed borylative ... See more keywords
Enantioselective Copper-Catalyzed Fukuyama Indole Synthesis from 2-Vinylphenyl Isocyanides.
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DOI: 10.1021/jacs.3c01667
Abstract: Enantioenriched chiral indoles are of high interest for the pharmaceutical and agrochemical industries. Herein, we present an asymmetric Fukuyama indole synthesis through a mild and efficient radical cascade reaction to access 2-fluoroalkylated 3-(α-cyanobenzylated) indoles by… read more here.
Keywords: indole synthesis; fukuyama indole; synthesis; enantioselective copper ... See more keywords
Enantioselective copper-catalysed defluorinative alkylation of polyfluoroarenes with alkenes and 1,3-dienes.
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DOI: 10.1039/d5sc08090h
Abstract: Despite impressive advances in the field of defluorinative alkylation of polyfluoroarenes, the corresponding asymmetric counterpart has remained a formidable challenge. Herein, we present the first example of asymmetric defluorinative alkylation of polyfluoroarenes with readily accessible… read more here.
Keywords: alkylation polyfluoroarenes; copper catalysed; alkenes dienes; defluorinative alkylation ... See more keywords