Chiral Phosphoric Acid Catalyzed Enantioselective [4 + 2] Cycloaddition Reaction of α-Fluorostyrenes with Imines.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03360
Abstract: An enantioselective [4 + 2] cycloaddition reaction of α-fluorostyrenes with N-benzoyl imines was demonstrated using a chiral phosphoric acid catalyst. Cycloaddition products having fluorine functionality were formed in high yields with excellent diastereo- and enantioselectivities.… read more here.
Keywords: cycloaddition; chiral phosphoric; phosphoric acid; enantioselective cycloaddition ... See more keywords
Enantioselective [6 + 2]-Cycloaddition of Transient 3-Methide-3H-pyrroles with 2-Vinylindoles under Chiral Brønsted Acid Catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02548
Abstract: An organocatalytic, highly diastereo- and enantioselective [6 + 2]-cycloaddition of 3-methide-3H-pyrroles with 2-vinylindoles has been developed. This BINOL phosphoric acid-catalyzed reaction utilizes pyrrole-3-carbinols as precursors for the in situ generation of 3-methide-3H-pyrroles to access densely… read more here.
Keywords: enantioselective cycloaddition; methide; acid; methide pyrroles ... See more keywords
Useful Applications of Enantioselective (4 + 2)-Cycloaddition Reactions to the Synthesis of Chiral 1,2-Amino Alcohols, 1,2-Diamines, and β-Amino Acids.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02437
Abstract: The scope of enantioselective (4 + 2)-cycloaddition reactions has been expanded to include reactive olefinic components that are equivalents of three inoperable and unstable ethylene derivatives: 1-hydroxy-2-aminoethylene, 1,2-diaminoethylene, and β-aminoacrylic acid. In this way, a… read more here.
Keywords: cycloaddition; applications enantioselective; cycloaddition reactions; reactions synthesis ... See more keywords
Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01451-1
Abstract: Optically active spirocyclic compounds play an important role in drug discovery, and new synthetic strategies for the efficient generation of spiro stereocenters are in much demand. Here we report a catalytic enantioselective cycloaddition using spirocyclic… read more here.
Keywords: enantioselective cycloaddition; cycloaddition spirocyclopropyl; diastereo enantioselective; spirocyclopropyl oxindoles ... See more keywords
Synthesis of pyranopyrazoles with a chiral quaternary carbon stereocenter via copper-catalyzed enantioselective [3 + 3] cycloaddition.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc07058d
Abstract: A copper-catalyzed enantioselective [3 + 3] cycloaddition of propargyl carbonates and pyrazolones has been disclosed. This reaction provided an efficient route to synthesize pyranopyrazoles containing a chiral quaternary carbon stereocenter in good yields with good… read more here.
Keywords: carbon stereocenter; enantioselective cycloaddition; chiral quaternary; quaternary carbon ... See more keywords