Thioallenoates in Catalytic Enantioselective [2+2]-Cycloadditions with Unactivated Alkenes.
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.04.028
Abstract: The application of thioallenoates to catalytic enantioselective [2+2]-cycloadditions with unactivated alkenes is reported.In many cases, the thioallenoates examined exhibit superior reactivity and selectivity compared to the alkoxy analogs generally used in these cycloadditions. read more here.
Keywords: thioallenoates catalytic; enantioselective cycloadditions; cycloadditions unactivated; catalytic enantioselective ... See more keywords
Disulfide-Bridged Peptides That Mediate Enantioselective Cycloadditions through Thiyl Radical Catalysis.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00364
Abstract: An enantioselective vinylcyclopropane ring-opening/cycloaddition cascade is described. The active thiyl radical catalysts are generated in situ via UV light-promoted homolysis of cystine-based dimers. Amide-functionalization of the peptide at the 4-proline position is essential for effective… read more here.
Keywords: mediate enantioselective; thiyl radical; enantioselective cycloadditions; disulfide bridged ... See more keywords
Palladium-Catalyzed Enantioselective Cycloadditions of Aliphatic 1,4-Dipoles: Access to Chiral Cyclohexanes and Spiro [2.4] heptanes.
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DOI: 10.1021/jacs.0c08348
Abstract: Design and exploration of new intermediates for chemo-, regio-, and stereoselective cycloadditions remain a formidable challenge in modern organic synthesis. Compared to the well-developed 1,3-dipolar cycloadditions, Pd-catalyzed1,4-dipolar cycloadditions are generally limited to specialized substrates due… read more here.
Keywords: aliphatic dipoles; spiro heptanes; enantioselective cycloadditions; palladium catalyzed ... See more keywords
Allenoates in Enantioselective [2+2] Cycloadditions: From a Mechanistic Curiosity to a Stereospecific Transformation.
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DOI: 10.1021/jacs.8b10008
Abstract: Identification of a novel catalyst-allenoate pair allows enantioselective [2+2] cycloaddition of α-methylstyrene. To understand the origin of selectivity, a detailed mechanistic investigation was conducted. Herein, two competing reaction pathways are proposed, which operate simultaneously and… read more here.
Keywords: curiosity stereospecific; curiosity; cycloadditions mechanistic; enantioselective cycloadditions ... See more keywords