Diastereo- and Enantioselective Dearomative [3 + 2] Cycloaddition Reaction of 2-Nitrobenzofurans with 3-Isothiocyanato Oxindoles.
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DOI: 10.1021/acs.orglett.7b03667
Abstract: Enantioselective dearomative [3 + 2] cycloaddition reaction of 2-nitrobenzofurans with 3-isothiocyanato oxindoles was developed. The reaction employs a chiral bis(oxazoline)/Zn(OTf)2 catalyst, allowing a practical, straightforward access to structurally diverse spirooxindoles containing a 2,3-dihydrobenzofuran motif and… read more here.
Keywords: dearomative cycloaddition; reaction nitrobenzofurans; nitrobenzofurans isothiocyanato; reaction ... See more keywords
Enantioselective Dearomative Alkynylation of Chromanones: Opportunities and Obstacles
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DOI: 10.1055/a-1811-8075
Abstract: A catalytic and highly enantioselective dearomative alkynylation of chromanones has been discovered that enables the construction of biologically relevant tertiary ether stereogenic centers. This methodology is robust, accommodating a variety of alkynes and chromanones. More… read more here.
Keywords: alkynylation chromanones; enantioselective dearomative; opportunities obstacles; dearomative alkynylation ... See more keywords