Catalytic Enantioselective Desymmetrization of Prochiral Triacylamines via Pseudopeptidic Guanidine-Guanidinium Catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02785
Abstract: Triacylamines with Cs symmetry have been explored in asymmetric organocatalysis, leading to the development of a novel catalytic enantioselective desymmetrization of prochiral triacylamines by methanolysis under the catalysis of chiral pseudopeptidic guanidine-guanidinium salt having a… read more here.
Keywords: catalytic enantioselective; prochiral triacylamines; pseudopeptidic guanidine; enantioselective desymmetrization ... See more keywords
CuH-Catalyzed Enantioselective Desymmetrization of Cyclic 1,3-Diketones.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03359
Abstract: Herein, we report a CuH-catalyzed asymmetric desymmetrization of prochiral cyclopentane-1,3-diones to access cyclic 3-hydroxy ketones having an all-carbon quaternary center with high diastereoselectivity via hydrosilylation using PMHS as an inexpensive hydride source. This reaction displays… read more here.
Keywords: cuh catalyzed; desymmetrization cyclic; desymmetrization; enantioselective desymmetrization ... See more keywords
Enantioselective Desymmetrization of Bisphenol Derivatives via Ir-Catalyzed Allylic Dearomatization.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c09638
Abstract: Spirocyclic hexadienones with multiple stereogenic centers are frequently found in natural products but remain challenging targets to synthesize. Herein, we report the enantioselective desymmetrization of bisphenol derivatives via Ir-catalyzed allylic dearomatization reactions, affording spirocyclic hexadienone… read more here.
Keywords: enantioselective desymmetrization; allylic dearomatization; catalyzed allylic; desymmetrization bisphenol ... See more keywords
Enantioselective Desymmetrization of 2-Aryl-1,3-propanediols by Direct O-Alkylation with a Rationally Designed Chiral Hemiboronic Acid Catalyst That Mitigates Substrate Conformational Poisoning.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c00759
Abstract: Enantioselective desymmetrization by direct monofunctionalization of prochiral diols is a powerful strategy to prepare valuable synthetic intermediates in high optical purity. Boron acids can activate diols toward nucleophilic additions; however, the design of stable chiral… read more here.
Keywords: enantioselective desymmetrization; desymmetrization aryl; aryl propanediols; catalyst ... See more keywords
Enantioselective Desymmetrization of 1,3-Diols by a Chiral DMAP Derivative
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DOI: 10.1246/cl.180697
Abstract: We developed an enantioselective desymmetrization of 1,3-diols by a chiral N,N-dimethyl-4-aminopyridine (DMAP) derivative containing a 1,1′-binaphthyl with tert-alcohol units. The reactions require... read more here.
Keywords: enantioselective desymmetrization; dmap derivative; chiral dmap; desymmetrization diols ... See more keywords