Highly Enantioselective, Hydrogen-Bond-Donor Catalyzed Additions to Oxetanes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c03991
Abstract: A precisely designed chiral squaramide derivative is shown to promote the highly enantioselective addition of trimethylsilyl bromide (TMSBr) to a broad variety of 3-substituted and 3,3-disubstituted oxetanes. The reaction provides direct and gen-eral access to… read more here.
Keywords: hydrogen bond; highly enantioselective; enantioselective hydrogen; bond donor ... See more keywords
Enantioselective hydrogen-bond-donor catalysis to access diverse stereogenic-at-P(V) compounds
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abp8488
Abstract: The stereoselective synthesis of molecules bearing stereogenic phosphorus(V) centers represents an enduring challenge in organic chemistry. Although stereospecific nucleophilic substitution at P(V) provides a general strategy for elaborating optically active P(V) compounds, existing methods for… read more here.
Keywords: catalysis; enantioselective hydrogen; hydrogen bond; hydrogen ... See more keywords