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Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04054
Abstract: A chiral carbene-catalyzed [3+3] annulation of α-bromoenals with 2-aminobenzimidazoles providing pyrimido[1,2-a]benzimidazoles has been described. This protocol features a broad scope and good functional group tolerance. Biological studies indicated that the formed pyrimido[1,2-a]benzimidazole exhibited moderate cytotoxic…
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Keywords:
annulation bromoenals;
bromoenals aminobenzimidazoles;
nhc catalyzed;
catalyzed annulation ... See more keywords