Diastereo- and enantioselective phase-transfer alkylation of 3-substituted oxindoles with racemic secondary alkyl halides.
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DOI: 10.1039/c7cc07122a
Abstract: A catalytic asymmetric alkylation of fully substituted enolates with racemic, non-activated secondary alkyl halides is described. The chiral 1,2,3-triazolium ion enables excellent diastereo- and enantiocontrol via enantiofacial discrimination of prochiral enolates and kinetic resolution of… read more here.
Keywords: alkyl halides; diastereo enantioselective; enantioselective phase; alkylation ... See more keywords