Catalytic Enantioselective Reductive Cross Coupling of Electron-Deficient Olefins.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01801
Abstract: We report an enantioselective reductive cross coupling of electron-deficient olefins. Using a visible-light-driven cooperative photoredox and chiral Brønsted acid-catalyzed reaction with a Hantzsch ester as the terminal reductant, various cyclic and acyclic enones with 2-vinylpyridines… read more here.
Keywords: electron deficient; coupling electron; reductive cross; cross coupling ... See more keywords
Highly Regio- and Enantioselective Reductive Coupling of Alkynes and Aldehydes via Photoredox Cobalt Dual Catalysis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c03527
Abstract: A Co-catalyzed highly regio- and enantioselective reductive coupling of alkynes and aldehydes has been developed under visible light photoredox dual catalysis. A variety of enantioenriched allylic alcohols have been obtained by using unsymmetrical internal alkynes… read more here.
Keywords: regio enantioselective; enantioselective reductive; alkynes aldehydes; reductive coupling ... See more keywords
Nickel-Catalyzed Enantioselective Reductive Arylation and Heteroarylation of Aldimines via an Elementary 1,4-Addition.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c00548
Abstract: Nickel catalysts of chiral pyrox ligands promoted enantioselective reductive arylation and heteroarylation of aldimines, using directly (hetero)aryl halides and sulfonates. The catalytic arylation can also be conducted with crude aldimines generated from condensation of aldehydes… read more here.
Keywords: reductive arylation; arylation; enantioselective reductive; arylation heteroarylation ... See more keywords
Enantioselective reductive allylic alkylation enabled by dual photoredox/palladium catalysis.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06705f
Abstract: A dual photoredox/palladium catalyzed regio- and enantioselective reductive cross-coupling of allylic acetates with tertiary/secondary alkyl bromides has been achieved, and Hantzsch ester is used as a homogeneous organic reductant. This straightforward protocol enables the stereoselective… read more here.
Keywords: reductive allylic; photoredox palladium; dual photoredox; enantioselective reductive ... See more keywords
Multicatalysis protocol enables direct and versatile enantioselective reductive transformations of secondary amides
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.ade3431
Abstract: The catalytic asymmetric geminal bis-nucleophilic addition to nonreactive functional groups is a type of highly desirable yet challenging transformation in organic chemistry. Here, we report the first catalytic asymmetric reductive/deoxygenative alkynylation of secondary amides. The… read more here.
Keywords: secondary amides; multicatalysis protocol; enantioselective reductive; protocol ... See more keywords