Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C-Aliphatic Homoallylic Amines.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02069
Abstract: Reported herein is a method for the efficient syntheses of optically active 1-alkyl homoallylic amines in yields up to 95%, 13.5:1 dr, and 98% ee under mild, aqueous reaction conditions, via the Rh-catalyzed asymmetric allylation… read more here.
Keywords: catalyzed allylation; enantioselective rhodium; homoallylic amines; rhodium catalyzed ... See more keywords
Highly Enantioselective Rhodium(I)-Catalyzed Alder-ene-type Cycloisomerization of 1,7-Enynes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04171
Abstract: The transition-metal-catalyzed asymmetric cycloisomerization of 1,7-enynes is regarded as a formidable challenge due to the poor ability of 1,7-enynes to serve as bidentate ligands to metal. In this Letter, a highly enantioselective rhodium(I)-catalyzed Alder-ene-type cycloisomerization… read more here.
Keywords: cycloisomerization enynes; enantioselective rhodium; catalyzed alder; cycloisomerization ... See more keywords
Highly Enantioselective Rhodium-Catalyzed Transfer Hydrogenation of Tetrasubstituted Olefins: Application toward the Synthesis of GPR40 Agonist MK-2305.
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DOI: 10.1021/acs.orglett.2c01021
Abstract: A highly efficient enantioselective synthesis for the potent G-protein-coupled receptor 40 agonist MK-2305 was developed. The key tetrasubstituted olefin was prepared via a stereoselective Mukaiyama aldol reaction/elimination sequence. The highly enantioselective rhodium-catalyzed transfer hydrogenation of… read more here.
Keywords: transfer hydrogenation; transfer; enantioselective rhodium; agonist 2305 ... See more keywords
Highly enantioselective rhodium-catalyzed cross-coupling of boronic acids and racemic allyl halides
Sign Up to like & getrecommendations! Published in 2019 at "Nature Protocols"
DOI: 10.1038/s41596-019-0209-8
Abstract: Although Csp 2–Csp 2 Suzuki–Miyaura couplings (SMCs) are widely used in small-molecule synthesis, related methods that allow the incorporation of Csp 3-hybridized coupling partners, particularly in an asymmetric manner, are less developed. This protocol describes… read more here.
Keywords: enantioselective rhodium; rhodium; rhodium catalyzed; highly enantioselective ... See more keywords