Pd(II)-Catalyzed Enantioselective C(sp3)–H Arylation of Cyclopropanes and Cyclobutanes Guided by Tertiary Alkylamines
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DOI: 10.1021/jacs.1c11921
Abstract: Strained aminomethyl-cycloalkanes are a recurrent scaffold in medicinal chemistry due to their unique structural features that give rise to a range of biological properties. Here, we report a palladium-catalyzed enantioselective C(sp3)–H arylation of aminomethyl-cyclopropanes and… read more here.
Keywords: cyclopropanes cyclobutanes; enantioselective sp3; tertiary alkylamines; sp3 arylation ... See more keywords
Enantioselective C(sp3)-H Functionalization of Oxacycles via Photo-HAT/Nickel Dual Catalysis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12481
Abstract: The selective functionalization of ubiquitous but inert C-H bonds is highly appealing in synthetic chemistry, but the direct transformation of hydrocarbons lacking directing groups into high-value chiral molecules remains a formidable challenge. Herein, we develop… read more here.
Keywords: sp3 functionalization; functionalization; enantioselective sp3; via photo ... See more keywords
Enantioselective C(sp3)-C(sp3) Reductive Cross-Electrophile Coupling of Unactivated Alkyl Halides with α-Chloroboronates via Dual Nickel/Photoredox Catalysis.
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DOI: 10.1021/jacs.2c13220
Abstract: Substantial advances in enantioconvergent C(sp3)-C(sp3) bond formations have been made with nickel-catalyzed cross-coupling of racemic alkyl electrophiles with organometallic reagents or nickel-hydride-catalyzed hydrocarbonation of alkenes. Herein, we report an unprecedented enantioselective C(sp3)-C(sp3) reductive cross-coupling by… read more here.
Keywords: sp3 reductive; sp3; enantioselective sp3; sp3 sp3 ... See more keywords
Controlling Pd(IV) reductive-elimination pathways enables Pd(II)-catalyzed enantioselective C(sp3)–H fluorination
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DOI: 10.1038/s41557-018-0048-1
Abstract: The development of a Pd(ii)-catalysed enantioselective fluorination of C(sp3)−H bonds would offer a new approach to making chiral organofluorines. However, such a strategy is particularly challenging because of the difficulty in differentiating prochiral C(sp3)−H bonds… read more here.
Keywords: reductive elimination; enantioselective sp3; sp3; sp3 fluorination ... See more keywords
Palladium-catalyzed intramolecular enantioselective C(sp3)–H insertion of donor/donor carbenes
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DOI: 10.1039/d2sc03524c
Abstract: Herein, the first palladium-catalyzed intramolecular enantioselective C(sp3)–H insertion reaction of donor–donor carbenes has been successfully achieved. This facile protocol enables the rapid construction of a collection of enantioenriched decorated indolines with two contiguous stereocenters in… read more here.
Keywords: donor donor; catalyzed intramolecular; palladium catalyzed; intramolecular enantioselective ... See more keywords