Atropisomeric Phosphine Ligands Bearing C-N Axial Chirality: Applications in Enantioselective Suzuki-Miyaura Cross-Coupling Towards the Assembly of Tetra-ortho-Substituted Biaryls.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c06240
Abstract: Biaryl phosphines bearing C(Ar)-C(Ar) axial chirality are commonly known and have been successfully applied in many asymmetric catalyses. Nevertheless, the development of a chiral ligand having an axially chiral C(Ar)-N backbone remains elusive due to… read more here.
Keywords: enantioselective suzuki; bearing axial; applications enantioselective; chirality applications ... See more keywords
An Enantioselective Suzuki–Miyaura Coupling To Form Axially Chiral Biphenols
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c06529
Abstract: Axial chirality features prominently in molecules of biological interest as well as chiral catalyst designs, and atropisomeric 2,2′-biphenols are particularly prevalent. Atroposelective metal-catalyzed cross-coupling is an attractive and modular approach to access enantioenriched biphenols, and… read more here.
Keywords: coupling form; miyaura coupling; suzuki miyaura; enantioselective suzuki ... See more keywords
Enantioselective Suzuki cross-coupling of 1,2-diboryl cyclopropanes
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc05789a
Abstract: Herein, we describe the catalytic enantioselective cross-coupling of 1,2-bisboronic esters. Prior work on group specific cross coupling is limited to the use of geminal bis-boronates. This desymmetrization provides a novel approach to prepare enantioenriched cyclopropyl… read more here.
Keywords: diboryl cyclopropanes; coupling diboryl; cross coupling; enantioselective suzuki ... See more keywords