Simple Enantioselective Syntheses of (2R,6R)-Hydroxynorketamine and Related Potential Rapid-Onset Antidepressants.
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DOI: 10.1021/acs.orglett.7b02498
Abstract: A novel strategy for accessing cyclic α-amino ketones enantioselectively has opened a simple synthetic route to the antidepressant (2R,6R)-hydroxynorketamine and numerous analogues. Mechanistically guided catalyst selection was essential in an initial olefin epoxidation step. In… read more here.
Keywords: potential rapid; hydroxynorketamine related; enantioselective syntheses; simple enantioselective ... See more keywords
Enantioselective Syntheses of Tricyclic Benzimidazoles via Intramolecular Allylic Aminations with Chiral-Bridged Biphenyl Phosphoramidite Ligands.
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DOI: 10.1021/acs.orglett.8b03640
Abstract: The first iridium-catalyzed enantioselective intramolecular allylic aminations of benzimidazole-tethered allylic carbonates were developed, providing three classes of tricyclic benzimidazoles bearing a tertiary carbon stereogenic center in high yields and excellent enantioselectivities (up to 99% yield,… read more here.
Keywords: tricyclic benzimidazoles; allylic aminations; chiral bridged; enantioselective syntheses ... See more keywords
Enantioselective Syntheses of Wickerols A and B
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DOI: 10.1021/jacs.3c00448
Abstract: The evolution of a successful strategy for the synthesis of the strained, cage-like antiviral diterpenoids wickerols A and B is described. Initial attempts to access the carbocyclic core were surprisingly challenging and in retrospect, presaged… read more here.
Keywords: stereochemistry; enantioselective syntheses; syntheses wickerols;
Efficient Enantioselective Syntheses of (+)-Dalesconol A and B.
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DOI: 10.1021/jacs.7b00783
Abstract: We herein report the first enantioselective syntheses of immunosuppressants (+)-dalesconol A and B in a highly efficient and concise manner, which features an efficient palladium-catalyzed enantioselective dearomative cyclization-kinetic resolution cascade to install the chiral all-carbon… read more here.
Keywords: syntheses dalesconol; enantioselective syntheses; efficient enantioselective;