Highly Enantioselective Synthesis and Anticancer Activities of Chiral Conjugated Diynols
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800458
Abstract: A chiral amino alcohol based ligand was found to promote the highly enantioselective addition of terminal conjugated diynes to aromatic and aliphatic aldehydes. The combination of easily available C2‐symmetric (R)‐ and (S)‐BINOL with Ti(OiPr)4, Zn… read more here.
Keywords: anticancer activities; chiral conjugated; conjugated diynols; highly enantioselective ... See more keywords
Enantioselective synthesis of (R)-Cinacalcet via cobalt-catalysed asymmetric Negishi cross-coupling.
Sign Up to like & getrecommendations! Published in 2019 at "Chirality"
DOI: 10.1002/chir.23085
Abstract: A novel enantioselective synthesis of (R)-cinacalcet with 99% enantiomeric excesses (ee) has been achieved. The main strategies of the approach include a gram-scale cobalt-catalysed asymmetric cross-coupling of racemic ester with arylzinc reagent, Hoffman-type rearrangement of… read more here.
Keywords: catalysed asymmetric; cobalt catalysed; synthesis cinacalcet; cross coupling ... See more keywords
Enantioselective Synthesis of Ferrocene‐ or Cymantrene‐Fused Planar‐Chiral Phospholes
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Inorganic Chemistry"
DOI: 10.1002/ejic.201600875
Abstract: Planar-chiral ferrocene-fused phosphole (S)-1a was prepared in an enantiomerically pure form by enantioselective transformation. The synthesis was started with Kagan's chiral ferrocenyl acetal (–)-2a, and bromo and (Z)-2-bromovinyl substituents were introduced at the 1- and… read more here.
Keywords: cymantrene fused; planar chiral; ferrocene; enantioselective synthesis ... See more keywords
Synthetic studies on pseudolaric acid B: Enantioselective synthesis of C4,C10-di-epi-trans-fused [5-7]-bicyclic skeleton
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2020.09.023
Abstract: Abstract Studies on the synthesis of antifungal and anticancer natural product, pseudolaric acid B, have led to the enantioselective synthesis of di-epi-trans-fused [5–7]-bicyclic core skeleton. The synthesis was achieved in 10 linear steps, which features… read more here.
Keywords: synthesis; epi trans; pseudolaric acid; fused bicyclic ... See more keywords
Enantioselective synthesis of indolo[2,3-b]-dihydrothiopyranones via [3+3] cycloaddition of chiral α,β-unsaturated acylammonium salts
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.09.024
Abstract: Abstract A nucleophile-catalyzed Michael addition/proton transfer/lactonization (NCMPL) organocascade process of chiral α,β-unsaturated acylammonium salts and indoline-2-thiones is described, which delivers the indolo[2,3-b]dihydrothiopyranone motifs in high yields (up to 97%) with good to excellent enantioselectivities (up… read more here.
Keywords: chiral unsaturated; acylammonium salts; unsaturated acylammonium; synthesis indolo ... See more keywords
First enantioselective synthesis of salinipostin A, a marine cyclic enol-phosphotriester isolated from Salinispora sp
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.07.008
Abstract: Abstract Salinipostins are cyclic enol-phosphotriesters isolated from a marine-derived Salinispora sp. as antimalarial compounds. Herein, the first enantioselective synthesis of salinipostin A was achieved. Organocatalyst-mediated asymmetric cyclopropanation and regioselective cyclopropane ring opening were the key… read more here.
Keywords: cyclic enol; synthesis salinipostin; first enantioselective; enantioselective synthesis ... See more keywords
Enantioselective synthesis of hetero-triarylmethanes by chiral phosphoric acid-catalyzed 1,4-addition of 3-substituted indoles with azadienes
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.152862
Abstract: Abstract An efficient catalytic enantioselective 1,4-addition reaction of 3-substituted indoles, pyrroles and furans with substitution of azadienes by a chrial phosphoric acid was developed. A large variety of C2 substituted triarylmethanes derivatives were achieved in… read more here.
Keywords: substituted indoles; phosphoric acid; addition; enantioselective synthesis ... See more keywords
Direct enantioselective synthesis of pyrrolizidines
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.152954
Abstract: Abstract Stereoselective synthesis of natural and unnatural compounds containing the pyrrolizidine skeleton is of immense interest to synthetic organic chemists due to their enormous biological importance. In addition to the numerous total synthetic approaches, the… read more here.
Keywords: preparation; direct enantioselective; synthesis; enantioselective synthesis ... See more keywords
Enantioselective Synthesis of Atropisomers via Vinylidene ortho-Quinone Methides (VQMs).
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00486
Abstract: ConspectusAtropisomers, arising from conformational restriction, are inherently chiral due to the intersecting dissymmetric planes. Since there are numerous applications of enantiopure atropisomers in catalyst design, drug discovery, and material science, the asymmetric preparation of these… read more here.
Keywords: enantioselective synthesis; chemistry; vinylidene ortho; synthesis ... See more keywords
Organocatalytic Enantioselective Synthesis of Axially Chiral Molecules: Development of Strategies and Skeletons.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00509
Abstract: ConspectusThe growing importance of axially chiral architectures in different scientific domains has unveiled shortcomings in terms of efficient synthetic access and skeletal variety. This account describes our strategies in answering these challenges within the organocatalytic… read more here.
Keywords: enantioselective synthesis; development; organocatalytic enantioselective; arylation ... See more keywords
Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation.
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DOI: 10.1021/acs.chemrev.1c00496
Abstract: Chiral amines are key structural motifs present in a wide variety of natural products, drugs, and other biologically active compounds. During the past decade, significant advances have been made with respect to the enantioselective synthesis… read more here.
Keywords: synthesis chiral; chiral amines; asymmetric hydrogenation; recent advances ... See more keywords